The limit fold change model: A practical approach for selecting differentially expressed genes from microarray data

@drdevangm @pwilmarth This 2002 Mutch paper really stuck with me, especially for blood. So if a top 20 protein changes 1.2-fold it could be huge, but the less abundant proteins may change quite a bit with possibly little effect. Then cytokines have big eff

RT @neely615: Why I dislike fold-change cutoffs (tl;dr variance varies by abundance). Mutch et al. 2002 "The limit fold change model: A pra…

Why I dislike fold-change cutoffs (tl;dr variance varies by abundance). Mutch et al. 2002 "The limit fold change model: A practical approach for selecting differentially expressed genes from microarray data" https://t.co/Tgk1sXxeIV