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Global profiling of alternative RNA splicing events provides insights into molecular differences between various types of hepatocellular carcinoma

Overview of attention for article published in BMC Genomics, August 2016
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Title
Global profiling of alternative RNA splicing events provides insights into molecular differences between various types of hepatocellular carcinoma
Published in
BMC Genomics, August 2016
DOI 10.1186/s12864-016-3029-z
Pubmed ID
Authors

Marie-Pier Tremblay, Victoria E. S. Armero, Andréa Allaire, Simon Boudreault, Camille Martenon-Brodeur, Mathieu Durand, Elvy Lapointe, Philippe Thibault, Maude Tremblay-Létourneau, Jean-Pierre Perreault, Michelle S. Scott, Martin Bisaillon

Abstract

Dysregulations in alternative splicing (AS) patterns have been associated with many human diseases including cancer. In the present study, alterations to the global RNA splicing landscape of cellular genes were investigated in a large-scale screen from 377 liver tissue samples using high-throughput RNA sequencing data. Our study identifies modifications in the AS patterns of transcripts encoded by more than 2500 genes such as tumor suppressor genes, transcription factors, and kinases. These findings provide insights into the molecular differences between various types of hepatocellular carcinoma (HCC). Our analysis allowed the identification of 761 unique transcripts for which AS is misregulated in HBV-associated HCC, while 68 are unique to HCV-associated HCC, 54 to HBV&HCV-associated HCC, and 299 to virus-free HCC. Moreover, we demonstrate that the expression pattern of the RNA splicing factor hnRNPC in HCC tissues significantly correlates with patient survival. We also show that the expression of the HBx protein from HBV leads to modifications in the AS profiles of cellular genes. Finally, using RNA interference and a reverse transcription-PCR screening platform, we examined the implications of cellular proteins involved in the splicing of transcripts involved in apoptosis and demonstrate the potential contribution of these proteins in AS control. This study provides the first comprehensive portrait of global changes in the RNA splicing signatures that occur in hepatocellular carcinoma. Moreover, these data allowed us to identify unique signatures of genes for which AS is misregulated in the different types of HCC.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 48 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Canada 1 2%
Unknown 47 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 11 23%
Student > Master 7 15%
Researcher 6 13%
Student > Bachelor 5 10%
Other 4 8%
Other 8 17%
Unknown 7 15%
Readers by discipline Count As %
Agricultural and Biological Sciences 14 29%
Biochemistry, Genetics and Molecular Biology 12 25%
Medicine and Dentistry 4 8%
Immunology and Microbiology 3 6%
Pharmacology, Toxicology and Pharmaceutical Science 2 4%
Other 6 13%
Unknown 7 15%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 September 2016.
All research outputs
#14,858,822
of 22,884,315 outputs
Outputs from BMC Genomics
#6,147
of 10,668 outputs
Outputs of similar age
#206,042
of 338,621 outputs
Outputs of similar age from BMC Genomics
#146
of 274 outputs
Altmetric has tracked 22,884,315 research outputs across all sources so far. This one is in the 33rd percentile – i.e., 33% of other outputs scored the same or lower than it.
So far Altmetric has tracked 10,668 research outputs from this source. They receive a mean Attention Score of 4.7. This one is in the 37th percentile – i.e., 37% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 338,621 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 36th percentile – i.e., 36% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 274 others from the same source and published within six weeks on either side of this one. This one is in the 39th percentile – i.e., 39% of its contemporaries scored the same or lower than it.