Title |
Assessment of virulence diversity of methicillin-resistant Staphylococcus aureus strains with a Drosophila melanogaster infection model
|
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Published in |
BMC Microbiology, November 2012
|
DOI | 10.1186/1471-2180-12-274 |
Pubmed ID | |
Authors |
Kaiyu Wu, John Conly, Michael Surette, Christopher Sibley, Sameer Elsayed, Kunyan Zhang |
Abstract |
Staphylococcus aureus strains with distinct genetic backgrounds have shown different virulence in animal models as well as associations with different clinical outcomes, such as causing infection in the hospital or the community. With S. aureus strains carrying diverse genetic backgrounds that have been demonstrated by gene typing and genomic sequences, it is difficult to compare these strains using mammalian models. Invertebrate host models provide a useful alternative approach for studying bacterial pathogenesis in mammals since they have conserved innate immune systems of biological defense. Here, we employed Drosophila melanogaster as a host model for studying the virulence of S. aureus strains. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Scientists | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 5% |
Brazil | 1 | 3% |
Unknown | 34 | 92% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 10 | 27% |
Student > Ph. D. Student | 6 | 16% |
Student > Bachelor | 4 | 11% |
Professor | 3 | 8% |
Student > Master | 3 | 8% |
Other | 7 | 19% |
Unknown | 4 | 11% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 14 | 38% |
Immunology and Microbiology | 6 | 16% |
Medicine and Dentistry | 5 | 14% |
Biochemistry, Genetics and Molecular Biology | 4 | 11% |
Nursing and Health Professions | 1 | 3% |
Other | 2 | 5% |
Unknown | 5 | 14% |