Title |
A phenotypic screening platform to identify small molecule modulators of Chlamydomonas reinhardtiigrowth, motility and photosynthesis
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Published in |
Genome Biology, November 2012
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DOI | 10.1186/gb-2012-13-11-r105 |
Pubmed ID | |
Authors |
Simon E Alfred, Anuradha Surendra, Chris Le, Ken Lin, Alexander Mok, Iain M Wallace, Michael Proctor, Malene L Urbanus, Guri Giaever, Corey Nislow |
Abstract |
ABSTRACT: Chemical biology, the interfacial discipline of using small molecules as probes to investigate biology, is a powerful approach of developing specific, rapidly acting tools that can be applied across organisms. The single-celled alga Chlamydomonas reinhardtii is an excellent model system because of its photosynthetic ability, cilia-related motility and simple genetics. We report the results of an automated fitness screen of 5,445 small molecules and subsequent assays on motility/phototaxis and photosynthesis. Cheminformatic analysis revealed active core structures and was used to construct a naïve Bayes model that successfully predicts algal bioactive compounds. |
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United Kingdom | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Science communicators (journalists, bloggers, editors) | 1 | 100% |
Mendeley readers
Geographical breakdown
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United States | 1 | 1% |
Unknown | 71 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 22 | 31% |
Researcher | 15 | 21% |
Student > Bachelor | 12 | 17% |
Student > Master | 10 | 14% |
Professor | 3 | 4% |
Other | 5 | 7% |
Unknown | 5 | 7% |
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Biochemistry, Genetics and Molecular Biology | 10 | 14% |
Computer Science | 3 | 4% |
Engineering | 2 | 3% |
Chemistry | 2 | 3% |
Other | 7 | 10% |
Unknown | 9 | 13% |