Title |
Comparative genomics and transcriptomics of trait-gene association
|
---|---|
Published in |
BMC Genomics, November 2012
|
DOI | 10.1186/1471-2164-13-669 |
Pubmed ID | |
Authors |
Sebastián Aguilar Pierlé, Michael J Dark, Dani Dahmen, Guy H Palmer, Kelly A Brayton |
Abstract |
The Order Rickettsiales includes important tick-borne pathogens, from Rickettsia rickettsii, which causes Rocky Mountain spotted fever, to Anaplasma marginale, the most prevalent vector-borne pathogen of cattle. Although most pathogens in this Order are transmitted by arthropod vectors, little is known about the microbial determinants of transmission. A. marginale provides unique tools for studying the determinants of transmission, with multiple strain sequences available that display distinct and reproducible transmission phenotypes. The closed core A. marginale genome suggests that any phenotypic differences are due to single nucleotide polymorphisms (SNPs). We combined DNA/RNA comparative genomic approaches using strains with different tick transmission phenotypes and identified genes that segregate with transmissibility. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
France | 1 | 50% |
Germany | 1 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Scientists | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Chile | 1 | 1% |
India | 1 | 1% |
Egypt | 1 | 1% |
Mexico | 1 | 1% |
United States | 1 | 1% |
Unknown | 63 | 93% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 17 | 25% |
Researcher | 17 | 25% |
Student > Master | 8 | 12% |
Student > Doctoral Student | 7 | 10% |
Student > Bachelor | 3 | 4% |
Other | 9 | 13% |
Unknown | 7 | 10% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 42 | 62% |
Biochemistry, Genetics and Molecular Biology | 4 | 6% |
Environmental Science | 3 | 4% |
Immunology and Microbiology | 3 | 4% |
Earth and Planetary Sciences | 2 | 3% |
Other | 6 | 9% |
Unknown | 8 | 12% |