Title |
A parallel genome-wide mRNA and microRNA profiling of the frontal cortex of HIV patients with and without HIV-associated dementia shows the role of axon guidance and downstream pathways in HIV-mediated neurodegeneration
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Published in |
BMC Genomics, November 2012
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DOI | 10.1186/1471-2164-13-677 |
Pubmed ID | |
Authors |
Li Zhou, Gulietta M Pupo, Priyanka Gupta, Bing Liu, Sieu L Tran, Raany Rahme, Bin Wang, Rejane Rua, Helen Rizos, Adam Carroll, Murray J Cairns, Nitin K Saksena |
Abstract |
HIV-associated dementia (HAD) is the most common dementia type in young adults less than 40 years of age. Although the neurotoxins, oxidative/metabolic stress and impaired activity of neurotrophic factors are believed to be underlying reasons for the development of HAD, the genomic basis, which ultimately defines the virus-host interaction and leads to neurologic manifestation of HIV disease is lacking. Therefore, identifying HIV fingerprints on the host gene machinery and its regulation by microRNA holds a great promise and potential for improving our understanding of HAD pathogenesis, its diagnosis and therapy. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 50% |
France | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 50% |
Scientists | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 1% |
United States | 1 | 1% |
Unknown | 65 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 15 | 22% |
Researcher | 13 | 19% |
Student > Master | 10 | 15% |
Student > Bachelor | 7 | 10% |
Other | 4 | 6% |
Other | 9 | 13% |
Unknown | 9 | 13% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 14 | 21% |
Agricultural and Biological Sciences | 11 | 16% |
Nursing and Health Professions | 6 | 9% |
Neuroscience | 5 | 7% |
Computer Science | 3 | 4% |
Other | 13 | 19% |
Unknown | 15 | 22% |