Indeed, although cancer-associated CTCF Like BORIS 11 ZnF protein targets many genomic repeats, it has a very distinct binding and functional preference for the human-specific families of transposable SVA elements Epigenetics & Chromatin (31 Aug 2016)
Indeed, Elena Pugacheva, Evgeny Teplyakov, Qiongfang Wu, Jingjing Li, et. al. have found earlier that human SVA repeats are preferentially bound by human BORIS in accord with exemplary results taken from https://t.co/Z6mL37Mtyt to provide more clarity on t
Remarkably, only the evolutionary youngest human CTCF-derived paralogous CTCFL gene @20q13 encodes immunogenic cancer/testis-specific BORIS antigen (CTA) with a highly distinct binding and functional preference for the human-specific SVA transposons. h
A newest class of humanoid SVA elements actively transposed in human genome, is regulated by CTCF-paralogous ZFP named BORIS. Self-renewal of the widely used differentiation-inducible human K562 cell line requires co-expression of BORIS together with CTCF.