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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Gut Pharmacomicrobiomics: the tip of an iceberg of complex interactions between drugs and gut-associated microbes
|
|---|---|
| Published in |
Gut Pathogens, November 2012
|
| DOI | 10.1186/1757-4749-4-16 |
| Pubmed ID | |
| Authors |
Rama Saad, Mariam R Rizkallah, Ramy K Aziz |
| Abstract |
The influence of resident gut microbes on xenobiotic metabolism has been investigated at different levels throughout the past five decades. However, with the advance in sequencing and pyrotagging technologies, addressing the influence of microbes on xenobiotics had to evolve from assessing direct metabolic effects on toxins and botanicals by conventional culture-based techniques to elucidating the role of community composition on drugs metabolic profiles through DNA sequence-based phylogeny and metagenomics. Following the completion of the Human Genome Project, the rapid, substantial growth of the Human Microbiome Project (HMP) opens new horizons for studying how microbiome compositional and functional variations affect drug action, fate, and toxicity (pharmacomicrobiomics), notably in the human gut. The HMP continues to characterize the microbial communities associated with the human gut, determine whether there is a common gut microbiome profile shared among healthy humans, and investigate the effect of its alterations on health. Here, we offer a glimpse into the known effects of the gut microbiota on xenobiotic metabolism, with emphasis on cases where microbiome variations lead to different therapeutic outcomes. We discuss a few examples representing how the microbiome interacts with human metabolic enzymes in the liver and intestine. In addition, we attempt to envisage a roadmap for the future implications of the HMP on therapeutics and personalized medicine. |
X Demographics
The data shown below were collected from the profiles of 10 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Canada | 1 | 10% |
| Australia | 1 | 10% |
| Egypt | 1 | 10% |
| Unknown | 7 | 70% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 5 | 50% |
| Practitioners (doctors, other healthcare professionals) | 3 | 30% |
| Scientists | 2 | 20% |
Mendeley readers
The data shown below were compiled from readership statistics for 229 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Brazil | 4 | 2% |
| United States | 4 | 2% |
| Canada | 2 | <1% |
| Netherlands | 1 | <1% |
| Spain | 1 | <1% |
| Sri Lanka | 1 | <1% |
| Unknown | 216 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 60 | 26% |
| Student > Ph. D. Student | 45 | 20% |
| Student > Master | 34 | 15% |
| Student > Bachelor | 21 | 9% |
| Student > Postgraduate | 10 | 4% |
| Other | 33 | 14% |
| Unknown | 26 | 11% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 84 | 37% |
| Biochemistry, Genetics and Molecular Biology | 30 | 13% |
| Medicine and Dentistry | 19 | 8% |
| Pharmacology, Toxicology and Pharmaceutical Science | 16 | 7% |
| Nursing and Health Professions | 14 | 6% |
| Other | 30 | 13% |
| Unknown | 36 | 16% |
Attention Score in Context
This research output has an Altmetric Attention Score of 50. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 October 2023.
All research outputs
#819,171
of 24,953,268 outputs
Outputs from Gut Pathogens
#12
of 585 outputs
Outputs of similar age
#6,085
of 288,893 outputs
Outputs of similar age from Gut Pathogens
#2
of 12 outputs
Altmetric has tracked 24,953,268 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 96th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 585 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.6. This one has done particularly well, scoring higher than 98% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 288,893 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this research output to 12 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 91% of its contemporaries.