Title |
LRRK2 kinase inhibition prevents pathological microglial phagocytosis in response to HIV-1 Tat protein
|
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Published in |
Journal of Neuroinflammation, November 2012
|
DOI | 10.1186/1742-2094-9-261 |
Pubmed ID | |
Authors |
Daniel F Marker, Jenna M Puccini, Taryn E Mockus, Justin Barbieri, Shao-Ming Lu, Harris A Gelbard |
Abstract |
Human Immunodeficiency Virus-1 (HIV-1) associated neurocognitive disorders (HANDs) are accompanied by significant morbidity, which persists despite the use of combined antiretroviral therapy (cART). While activated microglia play a role in pathogenesis, changes in their immune effector functions, including phagocytosis and proinflammatory signaling pathways, are not well understood. We have identified leucine-rich repeat kinase 2 (LRRK2) as a novel regulator of microglial phagocytosis and activation in an in vitro model of HANDs, and hypothesize that LRRK2 kinase inhibition will attenuate microglial activation during HANDs. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 90 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 23 | 26% |
Student > Master | 13 | 14% |
Researcher | 11 | 12% |
Student > Bachelor | 9 | 10% |
Student > Doctoral Student | 5 | 6% |
Other | 8 | 9% |
Unknown | 21 | 23% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 18 | 20% |
Neuroscience | 16 | 18% |
Biochemistry, Genetics and Molecular Biology | 11 | 12% |
Medicine and Dentistry | 11 | 12% |
Immunology and Microbiology | 2 | 2% |
Other | 8 | 9% |
Unknown | 24 | 27% |