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Investigation of the Immunomodulatory effect of Berberis vulgaris on core-pulsed dendritic cell vaccine

Overview of attention for article published in BMC Complementary and Alternative Medicine, August 2016
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Mentioned by

twitter
1 tweeter

Citations

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5 Dimensions

Readers on

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15 Mendeley
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Title
Investigation of the Immunomodulatory effect of Berberis vulgaris on core-pulsed dendritic cell vaccine
Published in
BMC Complementary and Alternative Medicine, August 2016
DOI 10.1186/s12906-016-1327-2
Pubmed ID
Authors

Doaa A. Ghareeb, Eiman H. Elwakeel, Rowaida Khalil, Mina S. Aziz, Maha A. El demellawy

Abstract

Virus-induced dendritic cells (DCs) functional deficiency leads to sub-optimal initiation of adaptive immune responses and consequently chronic infection establishment. The present study reports an advanced hepatitis C virus (HCV) therapeutic vaccine model based on In vivo enrichment of DCs with barberry ethanolic crude extract (BCE) then pulsing them with HCV core protein. DCs were enriched by BCE intravenous injection in BALB/c mice. Vaccine efficiency was assessed by flow cytometric analysis of splenocytes of immunized mice, cytokine profiling, cytotoxic T lymphocyte assay, and humoral immune response assessment. There was no significant difference in surface phenotypic characterization of splenocytes from mice immunized with non-BCE-enriched-core-pulsed DCs (iDcs-core) compared to those from mice injected with RPMI-1640 medium. However, splenocytes from mice immunized with BCE-enriched-core-pulsed DCs showed 197 % increase in CD16+ population, 33 % increase in MHCII(+) population, and 43 % decrease in CD3(+) population. In iDCs-core group, 57.9 % greater anti-core cytotoxic T lymphocyte activity, up-regulation in interferon gamma and interleukin (IL) -12 expression, and down-regulation in IL-4 and IL-10 were recorded. Moreover, sustained specific anti-core antibodies were detected only in sera of the same group. results indicate that BCE-enriched-core-transduced DCs may serve as a new model for immunotherapy of HCV chronic infection.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 15 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Egypt 1 7%
Unknown 14 93%

Demographic breakdown

Readers by professional status Count As %
Professor 3 20%
Professor > Associate Professor 3 20%
Student > Bachelor 2 13%
Student > Ph. D. Student 1 7%
Lecturer > Senior Lecturer 1 7%
Other 2 13%
Unknown 3 20%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 5 33%
Pharmacology, Toxicology and Pharmaceutical Science 2 13%
Nursing and Health Professions 2 13%
Environmental Science 1 7%
Chemistry 1 7%
Other 0 0%
Unknown 4 27%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 September 2016.
All research outputs
#4,429,653
of 8,317,445 outputs
Outputs from BMC Complementary and Alternative Medicine
#1,158
of 2,093 outputs
Outputs of similar age
#138,834
of 251,837 outputs
Outputs of similar age from BMC Complementary and Alternative Medicine
#39
of 83 outputs
Altmetric has tracked 8,317,445 research outputs across all sources so far. This one is in the 27th percentile – i.e., 27% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,093 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.6. This one is in the 35th percentile – i.e., 35% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 251,837 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 34th percentile – i.e., 34% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 83 others from the same source and published within six weeks on either side of this one. This one is in the 49th percentile – i.e., 49% of its contemporaries scored the same or lower than it.