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Lymphatic imaging to assess rheumatoid flare: mechanistic insights and biomarker potential

Overview of attention for article published in Arthritis Research & Therapy, September 2016
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Title
Lymphatic imaging to assess rheumatoid flare: mechanistic insights and biomarker potential
Published in
Arthritis Research & Therapy, September 2016
DOI 10.1186/s13075-016-1092-0
Pubmed ID
Authors

Homaira Rahimi, Richard Bell, Echoe M. Bouta, Ronald W. Wood, Lianping Xing, Christopher T. Ritchlin, Edward M. Schwarz

Abstract

Proliferation of draining lymphatic vessels coupled with dynamic changes in lymph node volume and flow are characteristic features in rheumatoid arthritis (RA). Furthermore, impaired lymph egress from inflamed synovium is associated with joint flare in murine models of inflammatory-erosive arthritis. Unfortunately, advances towards a greater understanding of lymphatic changes in RA pathogenesis have been slow due to the absence of outcome measures to quantify lymphatic function in vivo. While lymphoscintigraphy is the current standard to assess lymphedema and sentinel lymph nodes in cancer patients, its sensitivity and specificity are inadequate to study lymphatics in RA. The emergence of high-resolution MRI, power Doppler ultrasound, and near-infrared imaging that permits real-time quantification of lymphatic function in animal models has been a major advance, and these techniques have produced a new paradigm of altered lymphatic function that underlies both acute arthritic flare and chronic inflammation. In acute flare, lymphatic drainage increases several fold, whereas no lymphatic contractions are detected in lymph vessels draining chronic arthritic joints. Moreover, these outcomes are now being adapted to study lymphatics in RA towards the development of novel biomarkers of arthritic flare and the discovery of new therapeutic targets. In particular, interventions that directly increase lymphatic egress from diseased joints by opening collateral lymphatic vessels, and that restore lymphatic vessel contractions, provide novel therapeutic approaches with potential for minimal toxicity and immunosuppression. To summarize the origins of this field, recent advances, and future directions, we herein review: current knowledge of lymphatics in RA based on classic literature; new in-vivo imaging modalities that have elucidated how lymphatics modulate acute versus chronic joint inflammation in murine models; and how these preclinical outcome measures are being translated to study lymphatic function in RA inflammation and how effective RA therapies alter lymphatic flow and lymph nodes draining flaring joints. ClinicalTrials.gov NCT02680067 . Registered 7 December 2015; ClinicalTrials.gov NCT01098201 . Registered 30 March 2010; and ClinicalTrials.gov NCT01083563 . Registered 8 March 2010.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 50 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 50 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 8 16%
Student > Master 6 12%
Researcher 5 10%
Student > Bachelor 5 10%
Professor 4 8%
Other 14 28%
Unknown 8 16%
Readers by discipline Count As %
Medicine and Dentistry 18 36%
Nursing and Health Professions 5 10%
Engineering 3 6%
Agricultural and Biological Sciences 3 6%
Pharmacology, Toxicology and Pharmaceutical Science 2 4%
Other 9 18%
Unknown 10 20%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 May 2017.
All research outputs
#15,982,793
of 25,373,627 outputs
Outputs from Arthritis Research & Therapy
#2,329
of 3,381 outputs
Outputs of similar age
#206,507
of 348,369 outputs
Outputs of similar age from Arthritis Research & Therapy
#29
of 50 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one is in the 36th percentile – i.e., 36% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,381 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.2. This one is in the 30th percentile – i.e., 30% of its peers scored the same or lower than it.
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We're also able to compare this research output to 50 others from the same source and published within six weeks on either side of this one. This one is in the 42nd percentile – i.e., 42% of its contemporaries scored the same or lower than it.