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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Apigenin and luteolin modulate microglial activation via inhibition of STAT1-induced CD40 expression
|
|---|---|
| Published in |
Journal of Neuroinflammation, September 2008
|
| DOI | 10.1186/1742-2094-5-41 |
| Pubmed ID | |
| Authors |
Kavon Rezai-Zadeh, Jared Ehrhart, Yun Bai, Paul R Sanberg, Paula Bickford, Jun Tan, R Douglas Shytle |
| Abstract |
It is well known that most neurodegenerative diseases are associated with microglia-mediated inflammation. Our previous research demonstrates that the CD40 signaling is critically involved in microglia-related immune responses in the brain. For example, it is well known that the activation of the signal transducer and activator of transcription (STAT) signaling pathway plays a central role in interferon-gamma (IFN-gamma)-induced microglial CD40 expression. We and others have previously reported that microglial CD40 expression is significantly induced by IFN-gamma and amyloid-beta (A beta) peptide. Recent studies have shown that certain flavonoids possess anti-inflammatory and neuroprotective properties distinct from their well-known anti-oxidant effects. In particular, flavonoids, apigenin and luteolin have been found to be effective CD40 immunomodulators. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 119 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | <1% |
| Spain | 1 | <1% |
| Brazil | 1 | <1% |
| Unknown | 116 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 23 | 19% |
| Researcher | 14 | 12% |
| Student > Master | 11 | 9% |
| Student > Bachelor | 11 | 9% |
| Student > Postgraduate | 9 | 8% |
| Other | 18 | 15% |
| Unknown | 33 | 28% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 27 | 23% |
| Biochemistry, Genetics and Molecular Biology | 14 | 12% |
| Medicine and Dentistry | 8 | 7% |
| Chemistry | 7 | 6% |
| Pharmacology, Toxicology and Pharmaceutical Science | 5 | 4% |
| Other | 14 | 12% |
| Unknown | 44 | 37% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 December 2015.
All research outputs
#7,825,522
of 25,067,172 outputs
Outputs from Journal of Neuroinflammation
#1,312
of 2,899 outputs
Outputs of similar age
#33,291
of 96,012 outputs
Outputs of similar age from Journal of Neuroinflammation
#4
of 5 outputs
Altmetric has tracked 25,067,172 research outputs across all sources so far. This one has received more attention than most of these and is in the 67th percentile.
So far Altmetric has tracked 2,899 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.7. This one has gotten more attention than average, scoring higher than 53% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 96,012 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 64% of its contemporaries.
We're also able to compare this research output to 5 others from the same source and published within six weeks on either side of this one.