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Reduced CYP2D6 function is associated with gefitinib-induced rash in patients with non-small cell lung cancer

Overview of attention for article published in BMC Cancer, December 2012
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1 X user

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Title
Reduced CYP2D6 function is associated with gefitinib-induced rash in patients with non-small cell lung cancer
Published in
BMC Cancer, December 2012
DOI 10.1186/1471-2407-12-568
Pubmed ID
Authors

Tomohiro Suzumura, Tatsuo Kimura, Shinzoh Kudoh, Kanako Umekawa, Misato Nagata, Kuniomi Matsuura, Hidenori Tanaka, Shigeki Mitsuoka, Naruo Yoshimura, Yukimi Kira, Toshiyuki Nakai, Kazuto Hirata

Abstract

Rash, liver dysfunction, and diarrhea are known major adverse events associated with erlotinib and gefitinib. However, clinical trials with gefitinib have reported different proportions of adverse events compared to trials with erlotinib. In an in vitro study, cytochrome P450 (CYP) 2D6 was shown to be involved in the metabolism of gefitinib but not erlotinib. It has been hypothesized that CYP2D6 phenotypes may be implicated in different adverse events associated with gefitinib and erlotinib therapies.

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 25 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 25 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 5 20%
Student > Master 5 20%
Student > Bachelor 4 16%
Lecturer 3 12%
Student > Ph. D. Student 3 12%
Other 4 16%
Unknown 1 4%
Readers by discipline Count As %
Medicine and Dentistry 6 24%
Agricultural and Biological Sciences 5 20%
Biochemistry, Genetics and Molecular Biology 4 16%
Pharmacology, Toxicology and Pharmaceutical Science 3 12%
Business, Management and Accounting 1 4%
Other 3 12%
Unknown 3 12%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 December 2012.
All research outputs
#18,321,703
of 22,687,320 outputs
Outputs from BMC Cancer
#5,415
of 8,250 outputs
Outputs of similar age
#215,615
of 277,752 outputs
Outputs of similar age from BMC Cancer
#72
of 108 outputs
Altmetric has tracked 22,687,320 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 8,250 research outputs from this source. They receive a mean Attention Score of 4.3. This one is in the 21st percentile – i.e., 21% of its peers scored the same or lower than it.
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We're also able to compare this research output to 108 others from the same source and published within six weeks on either side of this one. This one is in the 8th percentile – i.e., 8% of its contemporaries scored the same or lower than it.