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Shikonin enhances efficacy of a gene-based cancer vaccine via induction of RANTES

Overview of attention for article published in Journal of Biomedical Science, April 2012
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1 tweeter

Citations

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17 Dimensions

Readers on

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17 Mendeley

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Title
Shikonin enhances efficacy of a gene-based cancer vaccine via induction of RANTES
Published in
Journal of Biomedical Science, April 2012
DOI 10.1186/1423-0127-19-42
Pubmed ID
22494696
Authors

Hui-Ming Chen, Pi-Hsueh Wang, Kandan Aravindaram, Yun-Hsiang Chen, Hsiu-Hui Yu, Wen-Chin Yang, Ning-Sun Yang

Abstract

Shikonin, a phytochemical purified from Lithospermum erythrorhizon, has been shown to confer diverse pharmacological activities, including accelerating granuloma formation, wound healing, anti-inflammation and others, and is explored for immune-modifier activities for vaccination in this study. Transdermal gene-based vaccine is an attractive approach for delivery of DNA transgenes encoding specific tumor antigens to host skin tissues. Skin dendritic cells (DCs), a potent antigen-presenting cell type, is known to play a critical role in transmitting and orchestrating tumor antigen-specific immunities against cancers. The present study hence employs these various components for experimentation.

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Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 17 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 17 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 3 18%
Researcher 3 18%
Student > Bachelor 2 12%
Librarian 1 6%
Student > Ph. D. Student 1 6%
Other 3 18%
Unknown 4 24%
Readers by discipline Count As %
Medicine and Dentistry 4 24%
Agricultural and Biological Sciences 3 18%
Pharmacology, Toxicology and Pharmaceutical Science 2 12%
Arts and Humanities 2 12%
Unspecified 1 6%
Other 1 6%
Unknown 4 24%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 December 2012.
All research outputs
#12,357,523
of 18,796,975 outputs
Outputs from Journal of Biomedical Science
#558
of 843 outputs
Outputs of similar age
#165,699
of 271,939 outputs
Outputs of similar age from Journal of Biomedical Science
#19
of 34 outputs
Altmetric has tracked 18,796,975 research outputs across all sources so far. This one is in the 23rd percentile – i.e., 23% of other outputs scored the same or lower than it.
So far Altmetric has tracked 843 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.1. This one is in the 26th percentile – i.e., 26% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 271,939 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 29th percentile – i.e., 29% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 34 others from the same source and published within six weeks on either side of this one. This one is in the 26th percentile – i.e., 26% of its contemporaries scored the same or lower than it.

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