Title |
Shikonin enhances efficacy of a gene-based cancer vaccine via induction of RANTES
|
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Published in |
Journal of Biomedical Science, April 2012
|
DOI | 10.1186/1423-0127-19-42 |
Pubmed ID | |
Authors |
Hui-Ming Chen, Pi-Hsueh Wang, Kandan Aravindaram, Yun-Hsiang Chen, Hsiu-Hui Yu, Wen-Chin Yang, Ning-Sun Yang |
Abstract |
Shikonin, a phytochemical purified from Lithospermum erythrorhizon, has been shown to confer diverse pharmacological activities, including accelerating granuloma formation, wound healing, anti-inflammation and others, and is explored for immune-modifier activities for vaccination in this study. Transdermal gene-based vaccine is an attractive approach for delivery of DNA transgenes encoding specific tumor antigens to host skin tissues. Skin dendritic cells (DCs), a potent antigen-presenting cell type, is known to play a critical role in transmitting and orchestrating tumor antigen-specific immunities against cancers. The present study hence employs these various components for experimentation. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 16 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 3 | 19% |
Researcher | 3 | 19% |
Librarian | 1 | 6% |
Student > Ph. D. Student | 1 | 6% |
Other | 1 | 6% |
Other | 2 | 13% |
Unknown | 5 | 31% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 4 | 25% |
Agricultural and Biological Sciences | 3 | 19% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 13% |
Arts and Humanities | 2 | 13% |
Engineering | 1 | 6% |
Other | 0 | 0% |
Unknown | 4 | 25% |