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Mineralocorticoid and glucocorticoid receptors differentially regulate NF-kappaB activity and pro-inflammatory cytokine production in murine BV-2 microglial cells

Overview of attention for article published in Journal of Neuroinflammation, November 2012
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Title
Mineralocorticoid and glucocorticoid receptors differentially regulate NF-kappaB activity and pro-inflammatory cytokine production in murine BV-2 microglial cells
Published in
Journal of Neuroinflammation, November 2012
DOI 10.1186/1742-2094-9-260
Pubmed ID
Authors

Boonrat Chantong, Denise V Kratschmar, Lyubomir G Nashev, Zoltan Balazs, Alex Odermatt

Abstract

Microglia, the resident macrophage-like cells in the brain, regulate innate immune responses in the CNS to protect neurons. However, excessive activation of microglia contributes to neurodegenerative diseases. Corticosteroids are potent modulators of inflammation and mediate their effects by binding to mineralocorticoid receptors (MR) and glucocorticoid receptors (GR). Here, the coordinated activities of GR and MR on the modulation of the nuclear factor-κB (NF-κB) pathway in murine BV-2 microglial cells were studied.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 141 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Chile 1 <1%
Bulgaria 1 <1%
South Africa 1 <1%
United Kingdom 1 <1%
Canada 1 <1%
Japan 1 <1%
United States 1 <1%
Unknown 134 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 26 18%
Student > Master 23 16%
Researcher 21 15%
Student > Bachelor 14 10%
Student > Doctoral Student 8 6%
Other 27 19%
Unknown 22 16%
Readers by discipline Count As %
Agricultural and Biological Sciences 42 30%
Medicine and Dentistry 24 17%
Neuroscience 18 13%
Biochemistry, Genetics and Molecular Biology 14 10%
Pharmacology, Toxicology and Pharmaceutical Science 4 3%
Other 11 8%
Unknown 28 20%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 June 2016.
All research outputs
#18,323,689
of 22,689,790 outputs
Outputs from Journal of Neuroinflammation
#2,053
of 2,611 outputs
Outputs of similar age
#215,148
of 277,228 outputs
Outputs of similar age from Journal of Neuroinflammation
#19
of 22 outputs
Altmetric has tracked 22,689,790 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,611 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.6. This one is in the 12th percentile – i.e., 12% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 277,228 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 11th percentile – i.e., 11% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 22 others from the same source and published within six weeks on either side of this one. This one is in the 4th percentile – i.e., 4% of its contemporaries scored the same or lower than it.