Title |
Detection of Burkholderia pseudomallei O-antigen serotypes in near-neighbor species
|
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Published in |
BMC Microbiology, November 2012
|
DOI | 10.1186/1471-2180-12-250 |
Pubmed ID | |
Authors |
Joshua K Stone, Mark Mayo, Stephanie A Grasso, Jennifer L Ginther, Stephanie D Warrington, Christopher J Allender, Adina Doyle, Shalamar Georgia, Mirjam Kaestli, Stacey M Broomall, Mark A Karavis, Joseph M Insalaco, Kyle S Hubbard, Lauren A McNew, Henry S Gibbons, Bart J Currie, Paul Keim, Apichai Tuanyok |
Abstract |
Burkholderia pseudomallei is the etiological agent of melioidosis and a CDC category B select agent with no available effective vaccine. Previous immunizations in mice have utilized the lipopolysaccharide (LPS) as a potential vaccine target because it is known as one of the most important antigenic epitopes in B. pseudomallei. Complicating this strategy are the four different B. pseudomallei LPS O-antigen types: A, B, B2, and rough. Sero-crossreactivity is common among O-antigens of Burkholderia species. Here, we identified the presence of multiple B. pseudomallei O-antigen types and sero-crossreactivity in its near-neighbor species. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 24 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 6 | 25% |
Other | 4 | 17% |
Student > Master | 4 | 17% |
Student > Doctoral Student | 2 | 8% |
Professor | 1 | 4% |
Other | 2 | 8% |
Unknown | 5 | 21% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 4 | 17% |
Immunology and Microbiology | 4 | 17% |
Biochemistry, Genetics and Molecular Biology | 3 | 13% |
Veterinary Science and Veterinary Medicine | 2 | 8% |
Chemistry | 2 | 8% |
Other | 2 | 8% |
Unknown | 7 | 29% |