Title |
Sleep, aging, and lifespan in Drosophila
|
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Published in |
BMC Neuroscience, April 2010
|
DOI | 10.1186/1471-2202-11-56 |
Pubmed ID | |
Authors |
Daniel Bushey, Kimberly A Hughes, Giulio Tononi, Chiara Cirelli |
Abstract |
Epidemiological studies in humans suggest that a decrease in daily sleep duration is associated with reduced lifespan, but this issue remains controversial. Other studies in humans also show that both sleep quantity and sleep quality decrease with age. Drosophila melanogaster is a useful model to study aging and sleep, and inheriting mutations affecting the potassium current Shaker results in flies that sleep less and have a shorter lifespan. However, whether the link between short sleep and reduced longevity exists also in wild-type flies is unknown. Similarly, it is unknown whether such a link depends on sleep amount per se, rather than on other factors such as waking activity. Also, sleep quality has been shown to decrease in old flies, but it remains unclear whether aging-related sleep fragmentation is a generalized phenomenon. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Spain | 1 | 50% |
United States | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United Kingdom | 4 | 3% |
France | 1 | <1% |
Finland | 1 | <1% |
Germany | 1 | <1% |
Canada | 1 | <1% |
Japan | 1 | <1% |
United States | 1 | <1% |
Philippines | 1 | <1% |
Unknown | 145 | 93% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 36 | 23% |
Student > Ph. D. Student | 35 | 22% |
Student > Bachelor | 16 | 10% |
Professor > Associate Professor | 13 | 8% |
Student > Doctoral Student | 10 | 6% |
Other | 27 | 17% |
Unknown | 19 | 12% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 55 | 35% |
Neuroscience | 28 | 18% |
Biochemistry, Genetics and Molecular Biology | 22 | 14% |
Medicine and Dentistry | 14 | 9% |
Psychology | 4 | 3% |
Other | 9 | 6% |
Unknown | 24 | 15% |