Title |
The cell nuclei of skeletal muscle cells are transcriptionally active in hibernating edible dormice
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Published in |
BMC Molecular and Cell Biology, March 2009
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DOI | 10.1186/1471-2121-10-19 |
Pubmed ID | |
Authors |
Manuela Malatesta, Federica Perdoni, Serafina Battistelli, Sylviane Muller, Carlo Zancanaro |
Abstract |
Skeletal muscle is able to react in a rapid, dynamic way to metabolic and mechanical stimuli. In particular, exposure to either prolonged starvation or disuse results in muscle atrophy. At variance, in hibernating animals muscle atrophy may be scarce or absent after bouts of hibernation i.e., periods of prolonged (months) inactivity and food deprivation, and muscle function is fully preserved at arousal. In this study, myocytes from the quadriceps muscle of euthermic and hibernating edible dormice were investigated by a combination of morphological, morphometrical and immunocytochemical analyses at the light and electron microscopy level. The focus was on cell nuclei and mitochondria, which are highly sensitive markers of changing metabolic rate. |
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