In our previous work, we did a proof of concept for this where we focused on clumped PRS with varying p-value thresholds. Now with this update, we can tune any PRS model while accounting for LD. We also provide R2 estimates without requiring external data
RT @BioDecoded: PUMAS: fine-tuning polygenic risk scores with GWAS summary statistics | Genome Biology https://t.co/id0AIg1hAA #Bioinforma…
RT @BioDecoded: PUMAS: fine-tuning polygenic risk scores with GWAS summary statistics | Genome Biology https://t.co/id0AIg1hAA #Bioinforma…
RT @BioDecoded: PUMAS: fine-tuning polygenic risk scores with GWAS summary statistics | Genome Biology https://t.co/id0AIg1hAA #Bioinforma…