Title |
Identification and evaluation of novel synovial tissue biomarkers in rheumatoid arthritis by laser scanning cytometry
|
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Published in |
Arthritis Research & Therapy, January 2012
|
DOI | 10.1186/ar3682 |
Pubmed ID | |
Authors |
Christiane Fueldner, Anja Mittag, Jens Knauer, Maria Biskop, Pierre Hepp, Roger Scholz, Ulf Wagner, Ulrich Sack, Frank Emmrich, Attila Tárnok, Joerg Lehmann |
Abstract |
Suitable biomarkers are essential for therapeutic strategies in personalized medicine in terms of diagnosis as well as of prognosis. With highly specific biomarkers, it is possible, for example, to identify patients with poor prognosis, which enables early intervention and intensive treatment. The aim of this study was to identify and validate biomarkers and possible combinations for a prospective use in immunoscintigraphy, which may improve diagnosis of rheumatoid arthritis (RA) patients with consideration of inflammatory activity in the affected joints. Therefore, we tested several monoclonal antibodies (mAbs) directed against cellular-surface molecules on cells likely to be involved in the pathogenesis of RA. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 4% |
Denmark | 1 | 4% |
Unknown | 24 | 92% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 5 | 19% |
Researcher | 5 | 19% |
Student > Master | 5 | 19% |
Student > Doctoral Student | 3 | 12% |
Student > Bachelor | 2 | 8% |
Other | 3 | 12% |
Unknown | 3 | 12% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 9 | 35% |
Agricultural and Biological Sciences | 6 | 23% |
Immunology and Microbiology | 3 | 12% |
Biochemistry, Genetics and Molecular Biology | 1 | 4% |
Psychology | 1 | 4% |
Other | 3 | 12% |
Unknown | 3 | 12% |