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Longitudinal associations of lifestyle factors and weight status with insulin resistance (HOMA-IR) in preadolescent children: the large prospective cohort study IDEFICS

Overview of attention for article published in International Journal of Behavioral Nutrition and Physical Activity, September 2016
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  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (76th percentile)

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12 tweeters
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1 Facebook page

Citations

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41 Dimensions

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194 Mendeley
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Title
Longitudinal associations of lifestyle factors and weight status with insulin resistance (HOMA-IR) in preadolescent children: the large prospective cohort study IDEFICS
Published in
International Journal of Behavioral Nutrition and Physical Activity, September 2016
DOI 10.1186/s12966-016-0424-4
Pubmed ID
Authors

Jenny Peplies, Claudia Börnhorst, Kathrin Günther, Arno Fraterman, Paola Russo, Toomas Veidebaum, Michael Tornaritis, Stefaan De Henauw, Staffan Marild, Dénes Molnar, Luis A. Moreno, Wolfgang Ahrens

Abstract

This study investigates prospective associations of anthropometrical and lifestyle indices with insulin resistance (IR) in European children from the IDEFICS cohort. Insulin resistance (IR) is a growing concern in childhood obesity and a central aspect of the metabolic syndrome (MS). It most likely represents the link between obesity and type 2 diabetes. This longitudinal study included 3348 preadolescent children aged 3 to 10.9 years from 8 European countries who were observed from 2007/2008 to 2009/2010. The main outcome measure in the present analysis is HOMA-IR (homeostasis model assessment as a common proxy indicator to quantify IR) at follow-up and in its longitudinal development. Anthropometrical measures and lifestyle indices, including objectively determined physical activity, were considered, among others factors, as determinants of IR. Prospective associations between IR at follow-up and anthropometrical and lifestyle indices were estimated by logistic regression models. Country-specific prevalence rates of IR in the IDEFICS cohort of European children showed a positive trend with weight category. Prospective multivariate analyses showed the strongest positive associations of IR with BMI z-score (OR = 2.6 for unit change from the mean, 95 % CI 2.1-3.1) and z-score of waist circumference (OR = 2.2 for unit change from the mean, 95 % CI 1.9-2.6), which were analysed in separate models, but also for sex (OR = 2.2 for girls vs. boys, 95 % CI 1.5-3.1 up to OR 2.5, 95 % CI 1.8-3.6 depending on the model), audio-visual media time (OR = 1.2 for an additional hour per day, 95 % CI 1.0-1.4 in both models) and an inverse association of objectively determined physical activity (OR = 0.5 for 3(rd) compared to 1(st) quartile, 95 % CI 0.3-0.9 in both models). A longitudinal reduction of HOMA-IR was accompanied with a parallel decline in BMI. This study is, to our knowledge, the first prospective study on IR in a preadolescent children's population. It supports the common hypothesis that overweight and obesity are the main determinants of IR. Our data also indicate that physical inactivity and a sedentary lifestyle are likewise associated with the development of IR, independent of weight status. The promotion of physical activity should thus be considered as an equal option to dietary intervention for the treatment of IR in the paediatric practice.

Twitter Demographics

The data shown below were collected from the profiles of 12 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 194 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 194 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 33 17%
Student > Ph. D. Student 23 12%
Student > Bachelor 16 8%
Researcher 14 7%
Student > Doctoral Student 11 6%
Other 31 16%
Unknown 66 34%
Readers by discipline Count As %
Medicine and Dentistry 35 18%
Nursing and Health Professions 28 14%
Sports and Recreations 15 8%
Agricultural and Biological Sciences 5 3%
Biochemistry, Genetics and Molecular Biology 5 3%
Other 28 14%
Unknown 78 40%

Attention Score in Context

This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 March 2019.
All research outputs
#2,945,934
of 15,920,653 outputs
Outputs from International Journal of Behavioral Nutrition and Physical Activity
#979
of 1,565 outputs
Outputs of similar age
#62,035
of 266,820 outputs
Outputs of similar age from International Journal of Behavioral Nutrition and Physical Activity
#6
of 7 outputs
Altmetric has tracked 15,920,653 research outputs across all sources so far. Compared to these this one has done well and is in the 81st percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,565 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 24.1. This one is in the 37th percentile – i.e., 37% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 266,820 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 76% of its contemporaries.
We're also able to compare this research output to 7 others from the same source and published within six weeks on either side of this one.