Title |
iLOCi: a SNP interaction prioritization technique for detecting epistasis in genome-wide association studies
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Published in |
BMC Genomics, December 2012
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DOI | 10.1186/1471-2164-13-s7-s2 |
Pubmed ID | |
Authors |
Jittima Piriyapongsa, Chumpol Ngamphiw, Apichart Intarapanich, Supasak Kulawonganunchai, Anunchai Assawamakin, Chaiwat Bootchai, Philip J Shaw, Sissades Tongsima |
Abstract |
Genome-wide association studies (GWAS) do not provide a full account of the heritability of genetic diseases since gene-gene interactions, also known as epistasis are not considered in single locus GWAS. To address this problem, a considerable number of methods have been developed for identifying disease-associated gene-gene interactions. However, these methods typically fail to identify interacting markers explaining more of the disease heritability over single locus GWAS, since many of the interactions significant for disease are obscured by uninformative marker interactions e.g., linkage disequilibrium (LD). |
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Geographical breakdown
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Demographic breakdown
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Scientists | 2 | 67% |
Members of the public | 1 | 33% |
Mendeley readers
Geographical breakdown
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Denmark | 1 | 2% |
Germany | 1 | 2% |
Unknown | 48 | 92% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 18 | 35% |
Researcher | 9 | 17% |
Student > Master | 8 | 15% |
Student > Bachelor | 4 | 8% |
Student > Postgraduate | 4 | 8% |
Other | 9 | 17% |
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Engineering | 4 | 8% |
Medicine and Dentistry | 4 | 8% |
Other | 7 | 13% |
Unknown | 2 | 4% |