Title |
Efficacy of lisdexamfetamine dimesylate in adults with attention-deficit/hyperactivity disorder previously treated with amphetamines: analyses from a randomized, double-blind, multicenter, placebo-controlled titration study
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Published in |
BMC Pharmacology and Toxicology, December 2012
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DOI | 10.1186/2050-6511-13-18 |
Pubmed ID | |
Authors |
Thomas Babcock, Bryan Dirks, Ben Adeyi, Brian Scheckner |
Abstract |
To examine the efficacy of lisdexamfetamine dimesylate (LDX) in adults with attention-deficit/hyperactivity disorder (ADHD) who remained symptomatic (ADHD Rating Scale IV [ADHD-RS-IV] total score >18) on amphetamine (AMPH) therapy (mixed AMPH salts and/or d-AMPH formulations) prior to enrollment in a 4-week placebo-controlled LDX trial vs the overall study population. In these post hoc analyses from a multicenter, randomized, double-blind, forced-dose titration study, clinical efficacy of LDX (30-70 mg/d) in adults with ADHD receiving AMPH treatment at screening vs the overall study population was evaluated. ADHD symptoms were assessed using the ADHD-RS-IV with adult prompts at screening, baseline (after prior treatment washout), and endpoint. Safety assessments included treatment-emergent adverse events (TEAEs), vital signs, laboratory findings, and electrocardiogram. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Canada | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Brazil | 2 | 2% |
United States | 2 | 2% |
Israel | 1 | 1% |
India | 1 | 1% |
Unknown | 76 | 93% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 14 | 17% |
Student > Master | 11 | 13% |
Researcher | 10 | 12% |
Student > Ph. D. Student | 5 | 6% |
Other | 4 | 5% |
Other | 12 | 15% |
Unknown | 26 | 32% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 23 | 28% |
Psychology | 6 | 7% |
Pharmacology, Toxicology and Pharmaceutical Science | 5 | 6% |
Nursing and Health Professions | 5 | 6% |
Biochemistry, Genetics and Molecular Biology | 3 | 4% |
Other | 8 | 10% |
Unknown | 32 | 39% |