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Functional α7β2 nicotinic acetylcholine receptors expressed in hippocampal interneurons exhibit high sensitivity to pathological level of amyloid β peptides

Overview of attention for article published in BMC Neuroscience, December 2012
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  • Above-average Attention Score compared to outputs of the same age and source (60th percentile)

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Title
Functional α7β2 nicotinic acetylcholine receptors expressed in hippocampal interneurons exhibit high sensitivity to pathological level of amyloid β peptides
Published in
BMC Neuroscience, December 2012
DOI 10.1186/1471-2202-13-155
Pubmed ID
Authors

Qiang Liu, Yao Huang, Jianxin Shen, Scott Steffensen, Jie Wu

Abstract

β-amyloid (Aβ) accumulation is described as a hallmark of Alzheimer's disease (AD). Aβ perturbs a number of synaptic components including nicotinic acetylcholine receptors containing α7 subunits (α7-nAChRs), which are abundantly expressed in the hippocampus and found on GABAergic interneurons. We have previously demonstrated the existence of a novel, heteromeric α7β2-nAChR in basal forebrain cholinergic neurons that exhibits high sensitivity to acute Aβ exposure. To extend our previous work, we evaluated the expression and pharmacology of α7β2-nAChRs in hippocampal interneurons and their sensitivity to Aβ.

X Demographics

X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 62 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 2%
Denmark 1 2%
Unknown 60 97%

Demographic breakdown

Readers by professional status Count As %
Researcher 13 21%
Student > Ph. D. Student 12 19%
Student > Bachelor 10 16%
Student > Master 5 8%
Professor 3 5%
Other 8 13%
Unknown 11 18%
Readers by discipline Count As %
Agricultural and Biological Sciences 13 21%
Pharmacology, Toxicology and Pharmaceutical Science 9 15%
Neuroscience 8 13%
Biochemistry, Genetics and Molecular Biology 6 10%
Medicine and Dentistry 6 10%
Other 5 8%
Unknown 15 24%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 December 2012.
All research outputs
#18,616,159
of 23,881,329 outputs
Outputs from BMC Neuroscience
#836
of 1,265 outputs
Outputs of similar age
#215,685
of 285,720 outputs
Outputs of similar age from BMC Neuroscience
#11
of 33 outputs
Altmetric has tracked 23,881,329 research outputs across all sources so far. This one is in the 19th percentile – i.e., 19% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,265 research outputs from this source. They receive a mean Attention Score of 4.5. This one is in the 29th percentile – i.e., 29% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 285,720 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 21st percentile – i.e., 21% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 33 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 60% of its contemporaries.