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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Effects of monoclonal anti-PcrV antibody on Pseudomonas aeruginosa-induced acute lung injury in a rat model
|
|---|---|
| Published in |
Journal of Immune Based Therapies and Vaccines, August 2003
|
| DOI | 10.1186/1476-8518-1-2 |
| Pubmed ID | |
| Authors |
Karine Faure, Junichi Fujimoto, David W Shimabukuro, Temitayo Ajayi, Nobuaki Shime, Kiyoshi Moriyama, Edward G Spack, Jeanine P Wiener-Kronish, Teiji Sawa |
| Abstract |
BACKGROUND: The effects of the murine monoclonal anti-PcrV antibody Mab166 on acute lung injury induced by Pseudomonas aeruginosa were analyzed in a rat model. METHODS: Lung injury was induced by the instillation of P. aeruginosa strain PA103 directly into the left lungs of anesthetized rats. One hour after the bacterial instillation, rabbit polyclonal anti-PcrV IgG, murine monoclonal anti-PcrV IgG Mab166 or Mab166 Fab-fragments were administered intratracheally directly into the lungs. The degree of alveolar epithelial injury, amount of lung edema, decrease in oxygenation and extent of lung inflammation by histology were evaluated as independent parameters of acute lung injury. RESULTS: These parameters improved in rats that had received intratracheal instillation of either rabbit polyclonal anti-PcrV IgG, murine monoclonal anti-PcrV IgG Mab166 or Mab166 Fab-fragments in comparison with the control group. CONCLUSION: Mab166 and its Fab fragments have potential as adjuvant therapy for acute lung injury due to P. aeruginosa pneumonia. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| France | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Practitioners (doctors, other healthcare professionals) | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 37 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Iran, Islamic Republic of | 1 | 3% |
| Unknown | 36 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 9 | 24% |
| Professor > Associate Professor | 4 | 11% |
| Student > Bachelor | 3 | 8% |
| Lecturer | 3 | 8% |
| Student > Master | 3 | 8% |
| Other | 9 | 24% |
| Unknown | 6 | 16% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 14 | 38% |
| Biochemistry, Genetics and Molecular Biology | 6 | 16% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 5% |
| Computer Science | 2 | 5% |
| Chemistry | 2 | 5% |
| Other | 3 | 8% |
| Unknown | 8 | 22% |
Attention Score in Context
This research output has an Altmetric Attention Score of 17. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 November 2023.
All research outputs
#2,141,635
of 25,373,627 outputs
Outputs from Journal of Immune Based Therapies and Vaccines
#3
of 32 outputs
Outputs of similar age
#2,556
of 53,437 outputs
Outputs of similar age from Journal of Immune Based Therapies and Vaccines
#1
of 1 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 91st percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 32 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 18.1. This one scored the same or higher as 29 of them.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 53,437 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 95% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them