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Improvement of ovarian response and oocyte quality of aged female by administration of bone morphogenetic protein-6 in a mouse model

Overview of attention for article published in Reproductive Biology and Endocrinology, December 2012
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Title
Improvement of ovarian response and oocyte quality of aged female by administration of bone morphogenetic protein-6 in a mouse model
Published in
Reproductive Biology and Endocrinology, December 2012
DOI 10.1186/1477-7827-10-117
Pubmed ID
Authors

Seung S Park, Min J Park, Bo S Joo, Jong K Joo, Jung B Son, Kyu S Lee

Abstract

Advancing female age remains a difficult problem in infertility treatment. Ovarian angiogenesis plays an important role in follicular development and the activation of ovarian angiogenesis has been emerged as a new strategy for the improvement of age-related decline of oocyte quality. BMP-6 affect gonadotropin signals in granulosa cells and it promotes normal fertility by enabling appropriate response to LH and normal oocyte quality. BMP-6 has a potential role in regulation of angiogenesis and regulates the expression of inhibitor of DNA-binding proteins (Ids). Ids involved in the control and timing of follicle selection and granulosa cells differentiation. Especially, Id-1 is well-characterized target of BMP-6 signaling. Therefore, this study investigated whether co-administration of BMP-6 during superovulation process improves ovarian response, oocyte quality and expression of Id-1 and vascular endothelial growth factor (VEGF) in the ovary of aged female using a mouse model.

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X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 32 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 32 100%

Demographic breakdown

Readers by professional status Count As %
Unspecified 14 44%
Researcher 4 13%
Professor > Associate Professor 3 9%
Student > Doctoral Student 2 6%
Other 1 3%
Other 4 13%
Unknown 4 13%
Readers by discipline Count As %
Unspecified 14 44%
Agricultural and Biological Sciences 5 16%
Biochemistry, Genetics and Molecular Biology 4 13%
Medicine and Dentistry 2 6%
Veterinary Science and Veterinary Medicine 1 3%
Other 2 6%
Unknown 4 13%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 January 2013.
All research outputs
#20,178,031
of 22,691,736 outputs
Outputs from Reproductive Biology and Endocrinology
#828
of 966 outputs
Outputs of similar age
#248,381
of 280,252 outputs
Outputs of similar age from Reproductive Biology and Endocrinology
#25
of 31 outputs
Altmetric has tracked 22,691,736 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 966 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.9. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 280,252 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 31 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.