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Open-label add-on treatment trial of minocycline in fragile X syndrome

Overview of attention for article published in BMC Neurology, October 2010
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (89th percentile)
  • High Attention Score compared to outputs of the same age and source (90th percentile)

Mentioned by

blogs
1 blog
twitter
1 tweeter
patent
1 patent

Citations

dimensions_citation
179 Dimensions

Readers on

mendeley
146 Mendeley

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Title
Open-label add-on treatment trial of minocycline in fragile X syndrome
Published in
BMC Neurology, October 2010
DOI 10.1186/1471-2377-10-91
Pubmed ID
20937127
Authors

Carlo Paribello, Leeping Tao, Anthony Folino, Elizabeth Berry-Kravis, Michael Tranfaglia, Iryna M Ethell, Douglas W Ethell

Abstract

Fragile X syndrome (FXS) is a disorder characterized by a variety of disabilities, including cognitive deficits, attention-deficit/hyperactivity disorder, autism, and other socio-emotional problems. It is hypothesized that the absence of the fragile X mental retardation protein (FMRP) leads to higher levels of matrix metallo-proteinase-9 activity (MMP-9) in the brain. Minocycline inhibits MMP-9 activity, and alleviates behavioural and synapse abnormalities in fmr1 knockout mice, an established model for FXS. This open-label add-on pilot trial was conducted to evaluate safety and efficacy of minocycline in treating behavioural abnormalities that occur in humans with FXS.

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Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 146 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 3 2%
Netherlands 3 2%
Australia 1 <1%
United Kingdom 1 <1%
Russia 1 <1%
Colombia 1 <1%
Unknown 136 93%

Demographic breakdown

Readers by professional status Count As %
Researcher 27 18%
Student > Ph. D. Student 24 16%
Student > Doctoral Student 17 12%
Student > Master 17 12%
Student > Bachelor 15 10%
Other 26 18%
Unknown 20 14%
Readers by discipline Count As %
Medicine and Dentistry 33 23%
Agricultural and Biological Sciences 29 20%
Psychology 23 16%
Neuroscience 13 9%
Nursing and Health Professions 4 3%
Other 16 11%
Unknown 28 19%

Attention Score in Context

This research output has an Altmetric Attention Score of 11. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 April 2019.
All research outputs
#2,016,993
of 17,361,274 outputs
Outputs from BMC Neurology
#208
of 1,910 outputs
Outputs of similar age
#29,022
of 265,052 outputs
Outputs of similar age from BMC Neurology
#15
of 154 outputs
Altmetric has tracked 17,361,274 research outputs across all sources so far. Compared to these this one has done well and is in the 88th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,910 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.0. This one has done well, scoring higher than 89% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 265,052 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 89% of its contemporaries.
We're also able to compare this research output to 154 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 90% of its contemporaries.

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