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Open-label add-on treatment trial of minocycline in fragile X syndrome

Overview of attention for article published in BMC Neurology, October 2010
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (83rd percentile)
  • Good Attention Score compared to outputs of the same age and source (76th percentile)

Mentioned by

blogs
1 blog
patent
1 patent

Citations

dimensions_citation
199 Dimensions

Readers on

mendeley
194 Mendeley
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Title
Open-label add-on treatment trial of minocycline in fragile X syndrome
Published in
BMC Neurology, October 2010
DOI 10.1186/1471-2377-10-91
Pubmed ID
Authors

Carlo Paribello, Leeping Tao, Anthony Folino, Elizabeth Berry-Kravis, Michael Tranfaglia, Iryna M Ethell, Douglas W Ethell

Abstract

Fragile X syndrome (FXS) is a disorder characterized by a variety of disabilities, including cognitive deficits, attention-deficit/hyperactivity disorder, autism, and other socio-emotional problems. It is hypothesized that the absence of the fragile X mental retardation protein (FMRP) leads to higher levels of matrix metallo-proteinase-9 activity (MMP-9) in the brain. Minocycline inhibits MMP-9 activity, and alleviates behavioural and synapse abnormalities in fmr1 knockout mice, an established model for FXS. This open-label add-on pilot trial was conducted to evaluate safety and efficacy of minocycline in treating behavioural abnormalities that occur in humans with FXS.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 194 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Netherlands 3 2%
United States 3 2%
Australia 1 <1%
Colombia 1 <1%
Russia 1 <1%
United Kingdom 1 <1%
Unknown 184 95%

Demographic breakdown

Readers by professional status Count As %
Researcher 31 16%
Student > Ph. D. Student 28 14%
Student > Master 22 11%
Student > Doctoral Student 21 11%
Student > Bachelor 21 11%
Other 34 18%
Unknown 37 19%
Readers by discipline Count As %
Medicine and Dentistry 37 19%
Agricultural and Biological Sciences 32 16%
Psychology 26 13%
Neuroscience 20 10%
Nursing and Health Professions 7 4%
Other 28 14%
Unknown 44 23%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 April 2019.
All research outputs
#3,627,592
of 22,691,736 outputs
Outputs from BMC Neurology
#440
of 2,418 outputs
Outputs of similar age
#15,997
of 98,900 outputs
Outputs of similar age from BMC Neurology
#3
of 13 outputs
Altmetric has tracked 22,691,736 research outputs across all sources so far. Compared to these this one has done well and is in the 84th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,418 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.7. This one has done well, scoring higher than 81% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 98,900 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 83% of its contemporaries.
We're also able to compare this research output to 13 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 76% of its contemporaries.