RT @Prof_S_Taylor: This paper makes two key points. #1 PARG inhibitor sensitivity tracks with markers of DNA replication stress leading to…
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However, Kuramochi cells were >2 fold more sensitive to BdS. This was in line with the PARGi sensitivity trend established by the @Prof_S_Taylor lab in their recent publication (https://t.co/m4vn3Aztro). (➖) control compound, BdS-H2, was inactive at sim
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RT @JournalofExper1: 📌 Replication catastrophe is responsible for intrinsic 𝐏𝐀𝐑 𝐠𝐥𝐲𝐜𝐨𝐡𝐲𝐝𝐫𝐨𝐥𝐚𝐬𝐞 𝐢𝐧𝐡𝐢𝐛𝐢𝐭𝐨𝐫-𝐬𝐞𝐧𝐬𝐢𝐭𝐢𝐯𝐢𝐭𝐲 in 𝐩𝐚𝐭𝐢𝐞𝐧𝐭-𝐝𝐞𝐫𝐢𝐯𝐞𝐝 𝐨𝐯𝐚…
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📌 Replication catastrophe is responsible for intrinsic 𝐏𝐀𝐑 𝐠𝐥𝐲𝐜𝐨𝐡𝐲𝐝𝐫𝐨𝐥𝐚𝐬𝐞 𝐢𝐧𝐡𝐢𝐛𝐢𝐭𝐨𝐫-𝐬𝐞𝐧𝐬𝐢𝐭𝐢𝐯𝐢𝐭𝐲 in 𝐩𝐚𝐭𝐢𝐞𝐧𝐭-𝐝𝐞𝐫𝐢𝐯𝐞𝐝 𝐨𝐯𝐚𝐫𝐢𝐚𝐧 𝐜𝐚𝐧𝐜𝐞𝐫 models 💻 https://t.co/pw5COEDIb2 #OvarianCancer #PARGinhibitor #DNAreplication https://t.co/ZFwDKhq1va