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Clinical development of monoclonal antibody-based drugs in HIV and HCV diseases

Overview of attention for article published in BMC Medicine, January 2013
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (92nd percentile)
  • Average Attention Score compared to outputs of the same age and source

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21 X users

Citations

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39 Dimensions

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118 Mendeley
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Title
Clinical development of monoclonal antibody-based drugs in HIV and HCV diseases
Published in
BMC Medicine, January 2013
DOI 10.1186/1741-7015-11-4
Pubmed ID
Authors

Michela Flego, Alessandro Ascione, Maurizio Cianfriglia, Stefano Vella

Abstract

Today there are many licensed antiviral drugs, but the emergence of drug resistant strains sometimes invalidates the effects of the current therapies used in the treatment of infectious diseases. Compared to conventional antiviral drugs, monoclonal antibodies (mAbs) used as pharmacological molecules have particular physical characteristics and modes of action, and, therefore, they should be considered as a distinct therapeutic class. Despite being historically validated, antibodies may represent a novel tool for combatting infectious diseases. The current high cost of mAbs' production, storage and administration (by injection only) and the consequent obstacles to development are outweighed by mAbs' clinical advantages. These are related to a low toxicity combined with high specificity and versatility, which allows a specific antibody to mediate various biological effects, ranging from the virus neutralization mechanisms to the modulation of immune responses.This review briefly summarizes the recent technological advances in the field of immunoglobulin research, and the current status of mAb-based drugs in clinical trials for HIV and HCV diseases. For each clinical trial the available data are reported and the emerging conceptual problems of the employed mAbs are highlighted.This overview helps to give a clear picture of the efficacy and challenges of the mAbs in the field of these two infectious diseases which have such a global impact.

X Demographics

X Demographics

The data shown below were collected from the profiles of 21 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 118 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 <1%
United States 1 <1%
Netherlands 1 <1%
Unknown 115 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 20 17%
Student > Master 16 14%
Student > Bachelor 14 12%
Researcher 13 11%
Other 10 8%
Other 22 19%
Unknown 23 19%
Readers by discipline Count As %
Agricultural and Biological Sciences 33 28%
Medicine and Dentistry 14 12%
Biochemistry, Genetics and Molecular Biology 13 11%
Pharmacology, Toxicology and Pharmaceutical Science 7 6%
Immunology and Microbiology 4 3%
Other 23 19%
Unknown 24 20%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 15. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 September 2014.
All research outputs
#2,142,173
of 23,150,406 outputs
Outputs from BMC Medicine
#1,408
of 3,481 outputs
Outputs of similar age
#22,020
of 282,822 outputs
Outputs of similar age from BMC Medicine
#38
of 72 outputs
Altmetric has tracked 23,150,406 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 90th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,481 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 43.7. This one has gotten more attention than average, scoring higher than 59% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 282,822 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 92% of its contemporaries.
We're also able to compare this research output to 72 others from the same source and published within six weeks on either side of this one. This one is in the 48th percentile – i.e., 48% of its contemporaries scored the same or lower than it.