Title |
Closing the circle of germline and stem cells: the Primordial Stem Cell hypothesis
|
---|---|
Published in |
EvoDevo, January 2013
|
DOI | 10.1186/2041-9139-4-2 |
Pubmed ID | |
Authors |
Jordi Solana |
Abstract |
Germline determination is believed to occur by either preformation or epigenesis. Animals that undergo germ cell specification by preformation have a continuous germline. However, animals with germline determination by epigenesis have a discontinuous germline, with somatic cells intercalated. This vision is contrary to August Weismann's Germ Plasm Theory and has led to several controversies. Recent data from metazoans as diverse as planarians, annelids and sea urchins reveal the presence of pluripotent stem cell populations that express germ plasm components, despite being considered to be somatic. These data also show that germ plasm is continuous in some of these animals, despite their discontinuous germline. |
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Scientists | 1 | 50% |
Mendeley readers
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