Title |
A cell based high-throughput screening approach for the discovery of new inhibitors of respiratory syncytial virus
|
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Published in |
Virology Journal, January 2013
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DOI | 10.1186/1743-422x-10-19 |
Pubmed ID | |
Authors |
Dong-Hoon Chung, Blake P Moore, Daljit S Matharu, Jennifer E Golden, Clinton Maddox, Lynn Rasmussen, Melinda I Sosa, Subramaniam Ananthan, E Lucile White, Fuli Jia, Colleen B Jonsson, William E Severson |
Abstract |
Human respiratory syncytial virus (hRSV) is a highly contagious pathogen and is the most common cause of bronchiolitis and pneumonia for infants and children under one year of age. Worldwide, greater than 33 million children under five years of age are affected by hRSV resulting in three million hospitalizations and 200,000 deaths. However, severe lower respiratory tract disease may occur at any age, especially among the elderly or those with compromised cardiac, pulmonary, or immune systems. There is no vaccine commercially available. Existing therapies for the acute infection are ribavirin and the prophylactic humanized monoclonal antibody (Synagis® from MedImmune) that is limited to use in high risk pediatric patients. Thus, the discovery of new inhibitors for hRSV would be clinically beneficial. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 3 | 33% |
United Kingdom | 2 | 22% |
Unknown | 4 | 44% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 7 | 78% |
Science communicators (journalists, bloggers, editors) | 2 | 22% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Spain | 1 | 2% |
Belgium | 1 | 2% |
Unknown | 58 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 10 | 17% |
Researcher | 9 | 15% |
Student > Ph. D. Student | 6 | 10% |
Other | 5 | 8% |
Student > Postgraduate | 5 | 8% |
Other | 15 | 25% |
Unknown | 10 | 17% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 13 | 22% |
Agricultural and Biological Sciences | 11 | 18% |
Immunology and Microbiology | 9 | 15% |
Biochemistry, Genetics and Molecular Biology | 5 | 8% |
Chemistry | 3 | 5% |
Other | 7 | 12% |
Unknown | 12 | 20% |