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Stool substitute transplant therapy for the eradication of Clostridium difficile infection: ‘RePOOPulating’ the gut

Overview of attention for article published in Microbiome, January 2013
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#32 of 1,792)
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (85th percentile)

Citations

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625 Dimensions

Readers on

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933 Mendeley
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1 CiteULike
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Title
Stool substitute transplant therapy for the eradication of Clostridium difficile infection: ‘RePOOPulating’ the gut
Published in
Microbiome, January 2013
DOI 10.1186/2049-2618-1-3
Pubmed ID
Authors

Elaine O Petrof, Gregory B Gloor, Stephen J Vanner, Scott J Weese, David Carter, Michelle C Daigneault, Eric M Brown, Kathleen Schroeter, Emma Allen-Vercoe

Abstract

Fecal bacteriotherapy ('stool transplant') can be effective in treating recurrent Clostridium difficile infection, but concerns of donor infection transmission and patient acceptance limit its use. Here we describe the use of a stool substitute preparation, made from purified intestinal bacterial cultures derived from a single healthy donor, to treat recurrent C. difficile infection that had failed repeated standard antibiotics. Thirty-three isolates were recovered from a healthy donor stool sample. Two patients who had failed at least three courses of metronidazole or vancomycin underwent colonoscopy and the mixture was infused throughout the right and mid colon. Pre-treatment and post-treatment stool samples were analyzed by 16 S rRNA gene sequencing using the Ion Torrent platform.

X Demographics

X Demographics

The data shown below were collected from the profiles of 136 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 933 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 17 2%
Canada 7 <1%
United Kingdom 7 <1%
Denmark 3 <1%
Spain 2 <1%
Sweden 2 <1%
Chile 1 <1%
Brazil 1 <1%
Malaysia 1 <1%
Other 11 1%
Unknown 881 94%

Demographic breakdown

Readers by professional status Count As %
Researcher 164 18%
Student > Ph. D. Student 143 15%
Student > Bachelor 134 14%
Student > Master 100 11%
Other 58 6%
Other 185 20%
Unknown 149 16%
Readers by discipline Count As %
Agricultural and Biological Sciences 264 28%
Medicine and Dentistry 204 22%
Biochemistry, Genetics and Molecular Biology 109 12%
Immunology and Microbiology 71 8%
Engineering 22 2%
Other 91 10%
Unknown 172 18%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 339. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 March 2024.
All research outputs
#98,750
of 25,734,859 outputs
Outputs from Microbiome
#32
of 1,792 outputs
Outputs of similar age
#530
of 292,191 outputs
Outputs of similar age from Microbiome
#1
of 7 outputs
Altmetric has tracked 25,734,859 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,792 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 38.0. This one has done particularly well, scoring higher than 98% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 292,191 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 7 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them