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Stool substitute transplant therapy for the eradication of Clostridium difficile infection: ‘RePOOPulating’ the gut

Overview of attention for article published in Microbiome, January 2013
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#28 of 1,356)
  • High Attention Score compared to outputs of the same age (99th percentile)

Citations

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570 Dimensions

Readers on

mendeley
896 Mendeley
citeulike
1 CiteULike
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Title
Stool substitute transplant therapy for the eradication of Clostridium difficile infection: ‘RePOOPulating’ the gut
Published in
Microbiome, January 2013
DOI 10.1186/2049-2618-1-3
Pubmed ID
Authors

Elaine O Petrof, Gregory B Gloor, Stephen J Vanner, Scott J Weese, David Carter, Michelle C Daigneault, Eric M Brown, Kathleen Schroeter, Emma Allen-Vercoe

Abstract

Fecal bacteriotherapy ('stool transplant') can be effective in treating recurrent Clostridium difficile infection, but concerns of donor infection transmission and patient acceptance limit its use. Here we describe the use of a stool substitute preparation, made from purified intestinal bacterial cultures derived from a single healthy donor, to treat recurrent C. difficile infection that had failed repeated standard antibiotics. Thirty-three isolates were recovered from a healthy donor stool sample. Two patients who had failed at least three courses of metronidazole or vancomycin underwent colonoscopy and the mixture was infused throughout the right and mid colon. Pre-treatment and post-treatment stool samples were analyzed by 16 S rRNA gene sequencing using the Ion Torrent platform.

Twitter Demographics

The data shown below were collected from the profiles of 140 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 896 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 17 2%
Canada 7 <1%
United Kingdom 7 <1%
Denmark 3 <1%
Spain 2 <1%
Sweden 2 <1%
Chile 1 <1%
France 1 <1%
Brazil 1 <1%
Other 12 1%
Unknown 843 94%

Demographic breakdown

Readers by professional status Count As %
Researcher 163 18%
Student > Ph. D. Student 144 16%
Student > Bachelor 134 15%
Student > Master 97 11%
Other 55 6%
Other 179 20%
Unknown 124 14%
Readers by discipline Count As %
Agricultural and Biological Sciences 261 29%
Medicine and Dentistry 199 22%
Biochemistry, Genetics and Molecular Biology 108 12%
Immunology and Microbiology 72 8%
Engineering 22 2%
Other 89 10%
Unknown 145 16%

Attention Score in Context

This research output has an Altmetric Attention Score of 343. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 September 2022.
All research outputs
#73,999
of 22,150,339 outputs
Outputs from Microbiome
#28
of 1,356 outputs
Outputs of similar age
#509
of 296,924 outputs
Outputs of similar age from Microbiome
#1
of 1 outputs
Altmetric has tracked 22,150,339 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,356 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 40.6. This one has done particularly well, scoring higher than 98% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 296,924 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them