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Murraya koenigii leaf extract inhibits proteasome activity and induces cell death in breast cancer cells

Overview of attention for article published in BMC Complementary and Alternative Medicine, January 2013
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (86th percentile)
  • Good Attention Score compared to outputs of the same age and source (79th percentile)

Mentioned by

twitter
10 tweeters
facebook
3 Facebook pages
reddit
1 Redditor

Citations

dimensions_citation
29 Dimensions

Readers on

mendeley
62 Mendeley
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Title
Murraya koenigii leaf extract inhibits proteasome activity and induces cell death in breast cancer cells
Published in
BMC Complementary and Alternative Medicine, January 2013
DOI 10.1186/1472-6882-13-7
Pubmed ID
Authors

Bindu Noolu, Rajanna Ajumeera, Anitha Chauhan, Balakrishna Nagalla, Raghunath Manchala, Ayesha Ismail

Abstract

Inhibition of the proteolytic activity of 26S proteasome, the protein-degrading machine, is now considered a novel and promising approach for cancer therapy. Interestingly, proteasome inhibitors have been demonstrated to selectively kill cancer cells and also enhance the sensitivity of tumor cells to chemotherapeutic agents. Recently, polyphenols/flavonoids have been reported to inhibit proteasome activity. Murraya koenigii Spreng, a medicinally important herb of Indian origin, has been used for centuries in the Ayurvedic system of medicine. Here we show that Murraya koenigii leaves (curry leaves), a rich source of polyphenols, inhibit the proteolytic activity of the cancer cell proteasome, and cause cell death.

Twitter Demographics

The data shown below were collected from the profiles of 10 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 62 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Malaysia 1 2%
India 1 2%
Unknown 60 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 11 18%
Student > Master 9 15%
Student > Bachelor 9 15%
Researcher 8 13%
Student > Doctoral Student 5 8%
Other 10 16%
Unknown 10 16%
Readers by discipline Count As %
Agricultural and Biological Sciences 13 21%
Biochemistry, Genetics and Molecular Biology 8 13%
Medicine and Dentistry 7 11%
Chemistry 7 11%
Pharmacology, Toxicology and Pharmaceutical Science 3 5%
Other 10 16%
Unknown 14 23%

Attention Score in Context

This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 March 2014.
All research outputs
#2,280,247
of 16,641,846 outputs
Outputs from BMC Complementary and Alternative Medicine
#510
of 2,969 outputs
Outputs of similar age
#34,482
of 263,524 outputs
Outputs of similar age from BMC Complementary and Alternative Medicine
#45
of 223 outputs
Altmetric has tracked 16,641,846 research outputs across all sources so far. Compared to these this one has done well and is in the 86th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,969 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.6. This one has done well, scoring higher than 82% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 263,524 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 86% of its contemporaries.
We're also able to compare this research output to 223 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 79% of its contemporaries.