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Effect of dabrafenib on melanoma cell lines harbouring the BRAFV600D/Rmutations

Overview of attention for article published in BMC Cancer, January 2013
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Title
Effect of dabrafenib on melanoma cell lines harbouring the BRAFV600D/Rmutations
Published in
BMC Cancer, January 2013
DOI 10.1186/1471-2407-13-17
Pubmed ID
Authors

Giusy Gentilcore, Gabriele Madonna, Nicola Mozzillo, Antoni Ribas, Antonio Cossu, Giuseppe Palmieri, Paolo A Ascierto

Abstract

Conventional therapeutic agents are largely unsatisfactory into the treatment of malignant melanoma. Recently, an innovative approach based on inhibitors of the mutated BRAF gene (which represents the most prevalent alteration in melanoma patients) appears very promising from the clinical point of view. On this regard, a new compound, dabrafenib (GSK2118436), has been demonstrated to be effective in patients carrying the BRAFV600E/K mutations. We here tested dabrafenib for its capability to inhibit cell growth on primary melanoma cell lines, established from patients' tumour tissues and carrying the BRAFV600D/R mutations.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 46 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 46 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 11 24%
Student > Ph. D. Student 8 17%
Other 5 11%
Student > Bachelor 4 9%
Professor > Associate Professor 3 7%
Other 4 9%
Unknown 11 24%
Readers by discipline Count As %
Agricultural and Biological Sciences 13 28%
Medicine and Dentistry 8 17%
Biochemistry, Genetics and Molecular Biology 8 17%
Chemistry 3 7%
Immunology and Microbiology 2 4%
Other 1 2%
Unknown 11 24%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 January 2013.
All research outputs
#20,178,948
of 22,693,205 outputs
Outputs from BMC Cancer
#6,481
of 8,252 outputs
Outputs of similar age
#251,368
of 283,921 outputs
Outputs of similar age from BMC Cancer
#96
of 105 outputs
Altmetric has tracked 22,693,205 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 8,252 research outputs from this source. They receive a mean Attention Score of 4.3. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 283,921 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 105 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.