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Exposure of RML scrapie agent to a sodium percarbonate-based product and sodium dodecyl sulfate renders PrPScprotease sensitive but does not eliminate infectivity

Overview of attention for article published in BMC Veterinary Research, January 2013
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1 Facebook page

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20 Mendeley
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Title
Exposure of RML scrapie agent to a sodium percarbonate-based product and sodium dodecyl sulfate renders PrPScprotease sensitive but does not eliminate infectivity
Published in
BMC Veterinary Research, January 2013
DOI 10.1186/1746-6148-9-8
Pubmed ID
Authors

Jodi D Smith, Eric M Nicholson, Gregory H Foster, Justin J Greenlee

Abstract

Prions, the causative agents of the transmissible spongiform encephalopathies, are notoriously difficult to inactivate. Current decontamination recommendations by the World Health Organization include prolonged exposure to 1 N sodium hydroxide or > 20,000 ppm sodium hypochlorite, or autoclaving. For decontamination of large stainless steel surfaces and equipment as in abattoirs, for example, these methods are harsh or unsuitable. The current study was designed to evaluate the effectiveness of a commercial product containing sodium percarbonate to inactivate prions. Samples of mouse brain infected with a mouse-adapted strain of the scrapie agent (RML) were exposed to a sodium percarbonate-based product (SPC-P). Treated samples were evaluated for abnormal prion protein (PrPSc)-immunoreactivity by western blot analysis, and residual infectivity by mouse bioassay.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 20 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 20 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 8 40%
Student > Bachelor 3 15%
Professor 2 10%
Student > Doctoral Student 1 5%
Student > Ph. D. Student 1 5%
Other 3 15%
Unknown 2 10%
Readers by discipline Count As %
Agricultural and Biological Sciences 5 25%
Biochemistry, Genetics and Molecular Biology 3 15%
Veterinary Science and Veterinary Medicine 2 10%
Nursing and Health Professions 2 10%
Environmental Science 1 5%
Other 5 25%
Unknown 2 10%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 January 2013.
All research outputs
#20,178,948
of 22,693,205 outputs
Outputs from BMC Veterinary Research
#2,408
of 3,034 outputs
Outputs of similar age
#249,973
of 282,285 outputs
Outputs of similar age from BMC Veterinary Research
#69
of 81 outputs
Altmetric has tracked 22,693,205 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,034 research outputs from this source. They receive a mean Attention Score of 3.8. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 282,285 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 81 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.