Title |
CTGC motifs within the HIV core promoter specify Tat-responsive pre-initiation complexes
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Published in |
Retrovirology, July 2012
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DOI | 10.1186/1742-4690-9-62 |
Pubmed ID | |
Authors |
Emmanuelle Wilhelm, Marie-Christine Doyle, Isaac Nzaramba, Alexandre Magdzinski, Nancy Dumais, Brendan Bell |
Abstract |
HIV latency is an obstacle for the eradication of HIV from infected individuals. Stable post-integration latency is controlled principally at the level of transcription. The HIV trans-activating protein, Tat, plays a key function in enhancing HIV transcriptional elongation. The HIV core promoter is specifically required for Tat-mediated trans-activation of HIV transcription. In addition, the HIV core promoter has been shown to be a potential anti-HIV drug target. Despite the pivotal role of the HIV core promoter in the control of HIV gene expression, the molecular mechanisms that couple Tat function specifically to the HIV core promoter remain unknown. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Canada | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Practitioners (doctors, other healthcare professionals) | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Canada | 2 | 7% |
United States | 1 | 3% |
Unknown | 27 | 90% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 12 | 40% |
Student > Master | 4 | 13% |
Researcher | 3 | 10% |
Student > Bachelor | 3 | 10% |
Student > Doctoral Student | 1 | 3% |
Other | 2 | 7% |
Unknown | 5 | 17% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 12 | 40% |
Engineering | 3 | 10% |
Medicine and Dentistry | 2 | 7% |
Immunology and Microbiology | 2 | 7% |
Biochemistry, Genetics and Molecular Biology | 1 | 3% |
Other | 3 | 10% |
Unknown | 7 | 23% |