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Adeno-associated virus: from defective virus to effective vector

Overview of attention for article published in Virology Journal, May 2005
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (95th percentile)
  • High Attention Score compared to outputs of the same age and source (88th percentile)

Mentioned by

blogs
1 blog
patent
9 patents
wikipedia
4 Wikipedia pages

Citations

dimensions_citation
181 Dimensions

Readers on

mendeley
545 Mendeley
citeulike
2 CiteULike
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Title
Adeno-associated virus: from defective virus to effective vector
Published in
Virology Journal, May 2005
DOI 10.1186/1743-422x-2-43
Pubmed ID
Authors

Manuel AFV Gonçalves

Abstract

The initial discovery of adeno-associated virus (AAV) mixed with adenovirus particles was not a fortuitous one but rather an expression of AAV biology. Indeed, as it came to be known, in addition to the unavoidable host cell, AAV typically needs a so-called helper virus such as adenovirus to replicate. Since the AAV life cycle revolves around another unrelated virus it was dubbed a satellite virus. However, the structural simplicity plus the defective and non-pathogenic character of this satellite virus caused recombinant forms to acquire centre-stage prominence in the current constellation of vectors for human gene therapy. In the present review, issues related to the development of recombinant AAV (rAAV) vectors, from the general principle to production methods, tropism modifications and other emerging technologies are discussed. In addition, the accumulating knowledge regarding the mechanisms of rAAV genome transduction and persistence is reviewed. The topics on rAAV vectorology are supplemented with information on the parental virus biology with an emphasis on aspects that directly impact on vector design and performance such as genome replication, genetic structure, and host cell entry.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 545 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 4 <1%
United Kingdom 3 <1%
Russia 2 <1%
Netherlands 2 <1%
India 1 <1%
Israel 1 <1%
Germany 1 <1%
Korea, Republic of 1 <1%
Canada 1 <1%
Other 2 <1%
Unknown 527 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 126 23%
Researcher 94 17%
Student > Master 80 15%
Student > Bachelor 63 12%
Student > Doctoral Student 30 6%
Other 58 11%
Unknown 94 17%
Readers by discipline Count As %
Agricultural and Biological Sciences 182 33%
Biochemistry, Genetics and Molecular Biology 121 22%
Neuroscience 36 7%
Medicine and Dentistry 35 6%
Immunology and Microbiology 13 2%
Other 58 11%
Unknown 100 18%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 20. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 September 2021.
All research outputs
#1,905,860
of 25,542,788 outputs
Outputs from Virology Journal
#150
of 3,407 outputs
Outputs of similar age
#2,886
of 70,640 outputs
Outputs of similar age from Virology Journal
#2
of 9 outputs
Altmetric has tracked 25,542,788 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 92nd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,407 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 24.6. This one has done particularly well, scoring higher than 95% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 70,640 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 95% of its contemporaries.
We're also able to compare this research output to 9 others from the same source and published within six weeks on either side of this one. This one has scored higher than 7 of them.