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Generation of a new transgenic mouse model for assessment of tau gene silencing therapies

Overview of attention for article published in Alzheimer's Research & Therapy, September 2016
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2 X users
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1 Facebook page

Citations

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21 Mendeley
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Title
Generation of a new transgenic mouse model for assessment of tau gene silencing therapies
Published in
Alzheimer's Research & Therapy, September 2016
DOI 10.1186/s13195-016-0202-1
Pubmed ID
Authors

Susan Fromholt, Christian Reitano, Hilda Brown, Jada Lewis, David R. Borchelt

Abstract

Targeting the expression of genes has emerged as a potentially viable therapeutic approach to human disease. In Alzheimer's disease, therapies that silence the expression of tau could be a viable strategy to slow disease progression. We produced a novel strain of transgenic mice that could be used to assess the efficacy of gene knockdown therapies for human tau, in live mice. We designed a tetracycline-regulated transgene construct in which the cDNA for human tau was fused to ubiquitin and to luciferase to create a single fusion polyprotein, termed TUL. When expressed in brain, the TUL polyprotein was cleaved by ubiquitin-processing enzymes to release the luciferase as an independent protein, separating the half-life of luciferase from the long-lived tau protein. Treatment of bigenic tTA/TUL mice with doxycycline produced rapid declines in luciferase levels visualized by in vivo imaging and ex vivo enzyme measurement. This new mouse model can be used as a discovery tool in optimizing gene targeting therapeutics directed to reduce human tau mRNA levels.

X Demographics

X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 21 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 5%
Unknown 20 95%

Demographic breakdown

Readers by professional status Count As %
Student > Master 7 33%
Researcher 4 19%
Professor 2 10%
Other 1 5%
Student > Ph. D. Student 1 5%
Other 3 14%
Unknown 3 14%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 4 19%
Neuroscience 3 14%
Medicine and Dentistry 3 14%
Agricultural and Biological Sciences 2 10%
Unspecified 1 5%
Other 2 10%
Unknown 6 29%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 September 2016.
All research outputs
#13,988,427
of 22,886,568 outputs
Outputs from Alzheimer's Research & Therapy
#1,093
of 1,235 outputs
Outputs of similar age
#188,054
of 335,711 outputs
Outputs of similar age from Alzheimer's Research & Therapy
#14
of 15 outputs
Altmetric has tracked 22,886,568 research outputs across all sources so far. This one is in the 37th percentile – i.e., 37% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,235 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 25.7. This one is in the 11th percentile – i.e., 11% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 335,711 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 42nd percentile – i.e., 42% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 15 others from the same source and published within six weeks on either side of this one. This one is in the 6th percentile – i.e., 6% of its contemporaries scored the same or lower than it.