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Modelling concentrations of antimicrobial drugs: comparative pharmacokinetics of cephalosporin antimicrobials and accuracy of allometric scaling in food-producing and companion animals

Overview of attention for article published in BMC Veterinary Research, September 2016
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Title
Modelling concentrations of antimicrobial drugs: comparative pharmacokinetics of cephalosporin antimicrobials and accuracy of allometric scaling in food-producing and companion animals
Published in
BMC Veterinary Research, September 2016
DOI 10.1186/s12917-016-0817-2
Pubmed ID
Authors

Femke J. Taverne, Ingeborg M. van Geijlswijk, Dick J. J. Heederik, Jaap A. Wagenaar, Johan W. Mouton

Abstract

To optimize antimicrobial dosing in different animal species, pharmacokinetic information is necessary. Due to the plethora of cephalosporin antimicrobials and animal species in which they are used, assessment of pharmacokinetics in all species is unfeasible. In this study we aimed to describe pharmacokinetic data of cephalosporins by reviewing the available literature for food producing and companion animal species. We assessed the accuracy of interspecies extrapolation using allometric scaling techniques to determine pharmacokinetic characteristics of cephalosporins in animal species for which literature data is unavailable. We assessed the accuracy of allometric scaling by comparing the predicted and the published pharmacokinetic value in an animal species/humans not included in the allometric modelling. In general, excretion of cephalosporins takes place mainly through renal mechanisms in the unchanged form and volume of distribution is limited in all animal species. Differences in plasma protein binding capacity and elimination half-life are observed but available information was limited. Using allometric scaling, correlations between body weight (BW) and volume of distribution (Vd) and clearance (Cl) were R (2)  > 0.97 and R (2)  > 0.95 respectively for ceftazidime, ceftiofur, cefquinome and cefepime but not ceftriaxone. The allometric exponent ranged from 0.80 to 1.31 for Vd and 0.83 to 1.24 for Cl. Correlations on half-life ranged from R(2) 0.07-0.655 (literature) and R(2) 0.102-0.876 (calculated). Allometric scaling can be applied for interspecies extrapolation of cephalosporin pharmacokinetic parameters Vd and Cl, but not elimination half-life. We hypothesize that the accuracy could be improved by using more refined scaling techniques.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 17 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
France 1 6%
Unknown 16 94%

Demographic breakdown

Readers by professional status Count As %
Professor > Associate Professor 4 24%
Researcher 3 18%
Student > Ph. D. Student 2 12%
Other 2 12%
Professor 1 6%
Other 0 0%
Unknown 5 29%
Readers by discipline Count As %
Medicine and Dentistry 4 24%
Veterinary Science and Veterinary Medicine 3 18%
Pharmacology, Toxicology and Pharmaceutical Science 2 12%
Agricultural and Biological Sciences 1 6%
Social Sciences 1 6%
Other 1 6%
Unknown 5 29%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 September 2016.
All research outputs
#20,340,423
of 22,886,568 outputs
Outputs from BMC Veterinary Research
#2,420
of 3,054 outputs
Outputs of similar age
#291,904
of 334,695 outputs
Outputs of similar age from BMC Veterinary Research
#48
of 57 outputs
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