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Intertumor heterogeneity in vascularity and invasiveness of artificial melanoma brain metastases

Overview of attention for article published in Journal of Experimental & Clinical Cancer Research, December 2015
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Title
Intertumor heterogeneity in vascularity and invasiveness of artificial melanoma brain metastases
Published in
Journal of Experimental & Clinical Cancer Research, December 2015
DOI 10.1186/s13046-015-0264-0
Pubmed ID
Authors

Trude G. Simonsen, Jon-Vidar Gaustad, Einar K. Rofstad

Abstract

Patients diagnosed with melanoma brain metastases have few treatment options and poor prognosis, and improved treatment strategies for these patients require detailed understanding of the underlying pathobiology. In this investigation we studied the vascularity and invasiveness of artificial brain metastases established from four human melanoma cell lines. A-07, D-12, R-18, and U-25 cells transfected with GFP were injected intracerebrally and intra-arterially in nude mice. Moribund mice were killed and autopsied, and the brain was evaluated by fluorescence imaging or by histological examination. Expression and secretion of factors involved in angiogenesis and invasion were assessed by quantitative PCR, ELISA, and immunohistochemistry. The melanoma cells grew preferentially in the meninges and ventricles after intracerebral and intra-arterial injection. Intertumor heterogeneity in the aggressiveness of meningeal tumors reflected differences in angiogenic activity and expression of vascular endothelial growth factor A (VEGF-A) and interleukin 8 (IL-8). In contrast, growth and invasion of the brain parenchyma relied primarily on vascular co-option. The cell lines showed different patterns of invasion from meninges to the scull and from meninges to the brain parenchyma, and these differences were associated with differences in expression of the matrix metalloproteinases MMP-2 and MMP-9. Furthermore, the melanoma cells produced multiple brain lesions after intracerebral implantation by using the meningeal linings of the brain as transport routes. The melanoma cell lines showed different growth patterns in the brain, and these differences were associated with differences in expression of the angiogenic factors VEGF-A and IL-8 and the matrix metalloproteinases MMP-2 and MMP-9.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 24 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 24 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 7 29%
Student > Ph. D. Student 5 21%
Student > Master 5 21%
Student > Postgraduate 3 13%
Professor > Associate Professor 2 8%
Other 1 4%
Unknown 1 4%
Readers by discipline Count As %
Medicine and Dentistry 11 46%
Biochemistry, Genetics and Molecular Biology 3 13%
Neuroscience 3 13%
Immunology and Microbiology 2 8%
Pharmacology, Toxicology and Pharmaceutical Science 1 4%
Other 2 8%
Unknown 2 8%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 September 2016.
All research outputs
#22,759,802
of 25,374,647 outputs
Outputs from Journal of Experimental & Clinical Cancer Research
#1,967
of 2,379 outputs
Outputs of similar age
#338,614
of 396,230 outputs
Outputs of similar age from Journal of Experimental & Clinical Cancer Research
#19
of 29 outputs
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So far Altmetric has tracked 2,379 research outputs from this source. They receive a mean Attention Score of 4.8. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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We're also able to compare this research output to 29 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.