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Role of aerobic glycolysis in genetically engineered mouse models of cancer

Overview of attention for article published in BMC Biology, January 2013
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (90th percentile)
  • Above-average Attention Score compared to outputs of the same age and source (55th percentile)

Mentioned by

blogs
1 blog
twitter
5 tweeters
googleplus
1 Google+ user

Citations

dimensions_citation
9 Dimensions

Readers on

mendeley
39 Mendeley
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Title
Role of aerobic glycolysis in genetically engineered mouse models of cancer
Published in
BMC Biology, January 2013
DOI 10.1186/1741-7007-11-3
Pubmed ID
Authors

Chi V Dang

Abstract

The propensity of cancer cells to convert high levels of glucose to lactate through aerobic glycolysis has been intensively studied in vitro, and is now understood to be a metabolic adaptation that shunts glucose carbons toward building blocks for the growing cell, as well as producing ATP. Much less is known, however, about the role of aerobic glycolysis and glycolytic enzymes in vivo. A paper in Cancer and Metabolism now documents aerobic glycolysis in the proliferating neural progenitors that form the cerebellum in normal newborn mice, as well as in medulloblastoma tumors derived from these cells in transgenic mice. Hexokinase II is demonstrated to be an essential driver of the observed aerobic glycolysis and the malignancy of the tumors. See research article: http://www.cancerandmetabolism.com/content/1/1/2.

Twitter Demographics

The data shown below were collected from the profiles of 5 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 39 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 5%
United Kingdom 1 3%
India 1 3%
Canada 1 3%
Unknown 34 87%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 13 33%
Researcher 10 26%
Other 5 13%
Professor 3 8%
Professor > Associate Professor 3 8%
Other 5 13%
Readers by discipline Count As %
Agricultural and Biological Sciences 17 44%
Biochemistry, Genetics and Molecular Biology 11 28%
Medicine and Dentistry 6 15%
Neuroscience 2 5%
Physics and Astronomy 1 3%
Other 2 5%

Attention Score in Context

This research output has an Altmetric Attention Score of 13. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 March 2013.
All research outputs
#1,057,096
of 12,434,754 outputs
Outputs from BMC Biology
#369
of 1,118 outputs
Outputs of similar age
#24,760
of 255,528 outputs
Outputs of similar age from BMC Biology
#9
of 20 outputs
Altmetric has tracked 12,434,754 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 91st percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,118 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 18.1. This one has gotten more attention than average, scoring higher than 67% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 255,528 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 90% of its contemporaries.
We're also able to compare this research output to 20 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 55% of its contemporaries.