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Inhibition of the NEMO/IKKβ association complex formation, a novel mechanism associated with the NF-κB activation suppression by Withania somnifera’s key metabolite withaferin A

Overview of attention for article published in BMC Genomics, December 2010
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Title
Inhibition of the NEMO/IKKβ association complex formation, a novel mechanism associated with the NF-κB activation suppression by Withania somnifera’s key metabolite withaferin A
Published in
BMC Genomics, December 2010
DOI 10.1186/1471-2164-11-s4-s25
Pubmed ID
Authors

Abhinav Grover, Ashutosh Shandilya, Ankita Punetha, Virendra S Bisaria, Durai Sundar

Abstract

Nuclear Factor kappa B (NF-κB) is a transcription factor involved in the regulation of cell signaling responses and is a key regulator of cellular processes involved in the immune response, differentiation, cell proliferation, and apoptosis. The constitutive activation of NF-κB contributes to multiple cellular outcomes and pathophysiological conditions such as rheumatoid arthritis, asthma, inflammatory bowel disease, AIDS and cancer. Thus there lies a huge therapeutic potential beneath inhibition of NF-κB signalling pathway for reducing these chronic ailments. Withania somnifera, a reputed herb in ayurvedic medicine, comprises a large number of steroidal lactones known as withanolides which show plethora of pharmacological activities like anti- inflammatory, antitumor, antibacterial, antioxidant, anticonvulsive, and immunosuppressive. Though a few studies have been reported depicting the effect of WA (withaferin A) on suppression of NF-κB activation, the mechanism behind this is still eluding the researchers. The study conducted here is an attempt to explore NF-κB signalling pathway modulating capability of Withania somnifera's major constituent WA and to elucidate its possible mode of action using molecular docking and molecular dynamics simulations studies.

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Mendeley readers

The data shown below were compiled from readership statistics for 118 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
India 3 3%
Malaysia 1 <1%
United States 1 <1%
Germany 1 <1%
Unknown 112 95%

Demographic breakdown

Readers by professional status Count As %
Researcher 22 19%
Student > Ph. D. Student 21 18%
Student > Bachelor 14 12%
Student > Master 10 8%
Student > Postgraduate 9 8%
Other 25 21%
Unknown 17 14%
Readers by discipline Count As %
Agricultural and Biological Sciences 27 23%
Biochemistry, Genetics and Molecular Biology 18 15%
Medicine and Dentistry 18 15%
Chemistry 8 7%
Pharmacology, Toxicology and Pharmaceutical Science 7 6%
Other 13 11%
Unknown 27 23%