PDIA3 inhibits mitochondrial respiratory function in brain endothelial cells and C. elegans through STAT3 signaling and decreases survival after OGD

https://t.co/4P3WnWC0pP "Our data also suggest that PDIA3 plays a detrimental role under pathological conditions such as OGD, which mimics key aspects of ischemia."

https://t.co/4P3WnWC0pP "A general protein disulfide isomerase inhibitor can protect against reductions in ATP levels in an in vitro Huntington disease model, supporting the notion that PDIA3 might inhibit mitochondrial bioenergetic function."

https://t.co/4P3WnWC0pP "Finally, PDIA3 is present at ER-mitochondrial contact sites, suggesting a possible role for non-transcriptional regulation between these organelles."

https://t.co/4P3WnWC0pP "Within mitochondria, PDIA3 promotes the intrinsic apoptotic pathway and mitochondrial permeabilization." "Furthermore, PDIA3 can increase mitochondrial calcium uptake by transcriptionally upregulating the mitochondrial calcium un