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Comprehensive protein tyrosine phosphatase mRNA profiling identifies new regulators in the progression of glioma

Overview of attention for article published in Acta Neuropathologica Communications, September 2016
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Title
Comprehensive protein tyrosine phosphatase mRNA profiling identifies new regulators in the progression of glioma
Published in
Acta Neuropathologica Communications, September 2016
DOI 10.1186/s40478-016-0372-x
Pubmed ID
Authors

Annika M. Bourgonje, Kiek Verrijp, Jan T. G. Schepens, Anna C. Navis, Jolanda A. F. Piepers, Chantal B. C. Palmen, Monique van den Eijnden, Rob Hooft van Huijsduijnen, Pieter Wesseling, William P. J. Leenders, Wiljan J. A. J. Hendriks

Abstract

The infiltrative behavior of diffuse gliomas severely reduces therapeutic potential of surgical resection and radiotherapy, and urges for the identification of new drug-targets affecting glioma growth and migration. To address the potential role of protein tyrosine phosphatases (PTPs), we performed mRNA expression profiling for 91 of the 109 known human PTP genes on a series of clinical diffuse glioma samples of different grades and compared our findings with in silico knowledge from REMBRANDT and TCGA databases. Overall PTP family expression levels appeared independent of characteristic genetic aberrations associated with lower grade or high grade gliomas. Notably, seven PTP genes (DUSP26, MTMR4, PTEN, PTPRM, PTPRN2, PTPRT and PTPRZ1) were differentially expressed between grade II-III gliomas and (grade IV) glioblastomas. For DUSP26, PTEN, PTPRM and PTPRT, lower expression levels correlated with poor prognosis, and overexpression of DUSP26 or PTPRT in E98 glioblastoma cells reduced tumorigenicity. Our study represents the first in-depth analysis of PTP family expression in diffuse glioma subtypes and warrants further investigations into PTP-dependent signaling events as new entry points for improved therapy.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 38 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 38 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 7 18%
Researcher 7 18%
Student > Ph. D. Student 5 13%
Student > Master 4 11%
Student > Doctoral Student 2 5%
Other 3 8%
Unknown 10 26%
Readers by discipline Count As %
Medicine and Dentistry 8 21%
Biochemistry, Genetics and Molecular Biology 6 16%
Agricultural and Biological Sciences 5 13%
Neuroscience 4 11%
Economics, Econometrics and Finance 1 3%
Other 3 8%
Unknown 11 29%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 October 2017.
All research outputs
#18,469,995
of 22,886,568 outputs
Outputs from Acta Neuropathologica Communications
#1,238
of 1,383 outputs
Outputs of similar age
#258,245
of 337,400 outputs
Outputs of similar age from Acta Neuropathologica Communications
#26
of 30 outputs
Altmetric has tracked 22,886,568 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
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We're also able to compare this research output to 30 others from the same source and published within six weeks on either side of this one. This one is in the 6th percentile – i.e., 6% of its contemporaries scored the same or lower than it.