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The effect of increased lipoproteins levels on the disposition of vincristine in rat

Overview of attention for article published in Lipids in Health and Disease, September 2016
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Title
The effect of increased lipoproteins levels on the disposition of vincristine in rat
Published in
Lipids in Health and Disease, September 2016
DOI 10.1186/s12944-016-0318-0
Pubmed ID
Authors

Hadeel A. Khalil, Tarek S. Belal, Ahmed F. El-Yazbi, Dalia A. Hamdy

Abstract

Vincristine (VCR), an antineoplastic agent, is a key component in the treatment of acute lymphoblastic leukemia, lymphomas, rhabdomyosarcoma, neuroblastoma, and Wilms' tumor diseases. Recently, high incidence of hyperlipidemia was reported to be associated with allogenic hematopoietic stem cell transplantation and VCR/L-asparaginase therapy. The aim of this study is to test the effects of incremental increase in lipoproteins levels on vincristine disposition in rat. To study VCR pharmacokinetics and protein binding, rats (n = 25) were assigned to three groups, normal lipidemic (NL), intermediate (IHL) and extreme hyperlipidemic (HL). Hyperlipidemia was induced by ip injection of (1 g/Kg) poloxamer 407 in rats. Serial blood samples were collected using the pre-inserted jugular vein cannula for 72 h post VCR (0.15 mg/Kg) i.v. dose. VCR unbound fractions in NL, IHL and HL plasma were determined using ultrafiltration kits. VCR demonstrated a rapid distribution phase (6-8 h) followed by a slower elimination phase with a mean elimination t½ of ~ 14 h. VCR exhibited moderate binding to plasma proteins ~ 83 %. It showed a relatively small Vc (~0.17 L/Kg) and a larger Vβ (1.53 L/Kg) indicating good tissue distribution. As the lipoproteins levels were increased, no significant changes were noted in VCR unbound fraction, plasma concentration, or volume of distribution indicating low affinity to lipoprotein binding. Induced HL also did not affect VCR elimination where similar VCR AUC0-∞, Cl and elimination phase t½ were reported along the different lipemic groups. Incremental increase in lipoprotein levels resulted in no significant effect on VCR disposition as such ALL malignant lymphoma and allogenic hematopoietic stem cell transplantation patients need not to worry about HL-VCR interaction. Whether, HL can potentiate another drug-drug or drug-disease interaction involving VCR warrants further studying and monitoring to ensure therapeutic safety and efficiency.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 23 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 23 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 7 30%
Student > Bachelor 3 13%
Student > Master 2 9%
Student > Doctoral Student 1 4%
Professor 1 4%
Other 5 22%
Unknown 4 17%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 6 26%
Pharmacology, Toxicology and Pharmaceutical Science 6 26%
Agricultural and Biological Sciences 2 9%
Unspecified 1 4%
Nursing and Health Professions 1 4%
Other 3 13%
Unknown 4 17%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 September 2016.
All research outputs
#20,341,859
of 22,888,307 outputs
Outputs from Lipids in Health and Disease
#1,203
of 1,450 outputs
Outputs of similar age
#287,534
of 330,061 outputs
Outputs of similar age from Lipids in Health and Disease
#32
of 35 outputs
Altmetric has tracked 22,888,307 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,450 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.1. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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