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Effect of polymorphisms in the CD36 and STAT3 genes on different dietary interventions among patients with coronary artery disease: study protocol for a randomized controlled trial

Overview of attention for article published in Trials, September 2016
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2 tweeters

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6 Dimensions

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71 Mendeley
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Title
Effect of polymorphisms in the CD36 and STAT3 genes on different dietary interventions among patients with coronary artery disease: study protocol for a randomized controlled trial
Published in
Trials, September 2016
DOI 10.1186/s13063-016-1564-1
Pubmed ID
Authors

Vera Lucia Portal, Melissa Medeiros Markoski, Alexandre Schaan de Quadros, Sílvia Garofallo, Julia Lorenzon dos Santos, Aline Oliveira, Camila Wechenfelder, Viviane Paiva de Campos, Priscilla Azambuja Lopes de Souza, Luana Machado, Aline Marcadenti

Abstract

Cardiovascular disease has become a major health problem, and it has been associated with both environmental and genetic factors. Studies have shown that the Mediterranean Diet (MeDiet), or its components such as nuts and olive oil, may be strongly associated with the improvement of cardiovascular risk factors in specific populations. The purpose of the GENUTRI study is to investigate the interaction of genetics with cardiovascular risk factors in a non-Mediterranean population with coronary artery disease (CAD) according to three different diets: rich in pecan nuts, in extra-virgin olive oil or a control diet. The GENUTRI study is a single-center, randomized, open-label, parallel-group, 12-week pragmatic clinical trial conducted in patients aged 40 to 80 years and diagnosed with CAD. A standardized questionnaire will be applied to data collection and a blood sample will be obtained for lipid, glycemic and inflammatory profile evaluation. Polymorphisms in the CD36 and STAT3 genes will be detected using the TaqMan® SNP Genotyping Assay. Patients will be allocated in three groups: group 1: 30 g/day of pecan nuts; group 2: 30 ml/day of olive oil; and group 3: control diet. The primary outcome will consist of changes in LDL-cholesterol (in mg/dl) after 12 weeks of intervention. Studies have shown the beneficial effects of diets rich in nuts and olive oil mainly in the Mediterranean population. GENUTRI is a clinical trial focusing on the effects of nuts or olive oil supplementation in Brazilian individuals. Additionally, we will try to demonstrate that genetic polymorphisms linked to cardiovascular disease may modulate the effects of different diets on biochemical and inflammatory markers among these subjects. ClinicalTrials.gov Identifier: NCT02202265 (registered on 18 July 2014: first version).

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 71 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 71 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 12 17%
Researcher 7 10%
Student > Master 6 8%
Student > Doctoral Student 6 8%
Other 5 7%
Other 13 18%
Unknown 22 31%
Readers by discipline Count As %
Medicine and Dentistry 15 21%
Nursing and Health Professions 11 15%
Biochemistry, Genetics and Molecular Biology 4 6%
Agricultural and Biological Sciences 4 6%
Pharmacology, Toxicology and Pharmaceutical Science 2 3%
Other 4 6%
Unknown 31 44%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 September 2016.
All research outputs
#6,389,965
of 11,013,916 outputs
Outputs from Trials
#1,698
of 2,663 outputs
Outputs of similar age
#129,406
of 258,144 outputs
Outputs of similar age from Trials
#56
of 100 outputs
Altmetric has tracked 11,013,916 research outputs across all sources so far. This one is in the 41st percentile – i.e., 41% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,663 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.8. This one is in the 35th percentile – i.e., 35% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 258,144 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 48th percentile – i.e., 48% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 100 others from the same source and published within six weeks on either side of this one. This one is in the 42nd percentile – i.e., 42% of its contemporaries scored the same or lower than it.