Title |
Fetal asphyctic preconditioning modulates the acute cytokine response thereby protecting against perinatal asphyxia in neonatal rats
|
---|---|
Published in |
Journal of Neuroinflammation, January 2013
|
DOI | 10.1186/1742-2094-10-14 |
Pubmed ID | |
Authors |
Evi Vlassaks, Eveline Strackx, Johan SH Vles, Maria Nikiforou, Pilar Martinez-Martinez, Boris W Kramer, Antonio WD Gavilanes |
Abstract |
Perinatal asphyxia (PA) is a major cause of brain damage and neurodevelopmental impairment in infants. Recent investigations have shown that experimental sublethal fetal asphyxia (FA preconditioning) protects against a subsequent more severe asphyctic insult at birth. The molecular mechanisms of this protection have, however, not been elucidated. Evidence implicates that inflammatory cytokines play a protective role in the induction of ischemic tolerance in the adult brain. Accordingly, we hypothesize that FA preconditioning leads to changes in the fetal cytokine response, thereby protecting the newborn against a subsequent asphyctic insult. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Scientists | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 22 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 5 | 23% |
Student > Master | 4 | 18% |
Researcher | 3 | 14% |
Professor | 3 | 14% |
Other | 1 | 5% |
Other | 2 | 9% |
Unknown | 4 | 18% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 6 | 27% |
Computer Science | 2 | 9% |
Neuroscience | 2 | 9% |
Sports and Recreations | 2 | 9% |
Medicine and Dentistry | 2 | 9% |
Other | 2 | 9% |
Unknown | 6 | 27% |