Title |
From desk to bed: Computational simulations provide indication for rheumatoid arthritis clinical trials
|
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Published in |
BMC Systems Biology, January 2013
|
DOI | 10.1186/1752-0509-7-10 |
Pubmed ID | |
Authors |
Jennifer E Dent, Christine Nardini |
Abstract |
Rheumatoid arthritis (RA) is among the most common human systemic autoimmune diseases, affecting approximately 1% of the population worldwide. To date, there is no cure for the disease and current treatments show undesirable side effects. As the disease affects a growing number of individuals, and during their working age, the gathering of all information able to improve therapies--by understanding their and the disease mechanisms of action--represents an important area of research, benefiting not only patients but also societies. In this direction, network analysis methods have been used in previous work to further our understanding of this complex disease, leading to the identification of CRKL as a potential drug target for treatment of RA. Here, we use computational methods to expand on this work, testing the hypothesis in silico. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 5% |
Unknown | 21 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 4 | 18% |
Researcher | 4 | 18% |
Student > Doctoral Student | 3 | 14% |
Student > Master | 3 | 14% |
Student > Bachelor | 2 | 9% |
Other | 2 | 9% |
Unknown | 4 | 18% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 5 | 23% |
Agricultural and Biological Sciences | 5 | 23% |
Biochemistry, Genetics and Molecular Biology | 4 | 18% |
Nursing and Health Professions | 2 | 9% |
Sports and Recreations | 1 | 5% |
Other | 1 | 5% |
Unknown | 4 | 18% |