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Differential effects of garcinol and curcumin on histone and p53 modifications in tumour cells

Overview of attention for article published in BMC Cancer, January 2013
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  • Average Attention Score compared to outputs of the same age and source

Mentioned by

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3 X users
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1 Facebook page

Citations

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80 Dimensions

Readers on

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90 Mendeley
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Title
Differential effects of garcinol and curcumin on histone and p53 modifications in tumour cells
Published in
BMC Cancer, January 2013
DOI 10.1186/1471-2407-13-37
Pubmed ID
Authors

Hilary M Collins, Magdy K Abdelghany, Marie Messmer, Baigong Yue, Sian E Deeves, Karin B Kindle, Kempegowda Mantelingu, Akhmed Aslam, G Sebastiaan Winkler, Tapas K Kundu, David M Heery

Abstract

Post-translational modifications (PTMs) of histones and other proteins are perturbed in tumours. For example, reduced levels of acetylated H4K16 and trimethylated H4K20 are associated with high tumour grade and poor survival in breast cancer. Drug-like molecules that can reprogram selected histone PTMs in tumour cells are therefore of interest as potential cancer chemopreventive agents. In this study we assessed the effects of the phytocompounds garcinol and curcumin on histone and p53 modification in cancer cells, focussing on the breast tumour cell line MCF7.

X Demographics

X Demographics

The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 90 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 1%
United States 1 1%
Unknown 88 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 19 21%
Researcher 12 13%
Student > Bachelor 10 11%
Student > Master 9 10%
Student > Doctoral Student 6 7%
Other 16 18%
Unknown 18 20%
Readers by discipline Count As %
Agricultural and Biological Sciences 23 26%
Biochemistry, Genetics and Molecular Biology 16 18%
Pharmacology, Toxicology and Pharmaceutical Science 11 12%
Medicine and Dentistry 7 8%
Chemistry 4 4%
Other 9 10%
Unknown 20 22%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 November 2016.
All research outputs
#14,102,908
of 23,881,329 outputs
Outputs from BMC Cancer
#3,106
of 8,483 outputs
Outputs of similar age
#165,007
of 288,412 outputs
Outputs of similar age from BMC Cancer
#45
of 93 outputs
Altmetric has tracked 23,881,329 research outputs across all sources so far. This one is in the 39th percentile – i.e., 39% of other outputs scored the same or lower than it.
So far Altmetric has tracked 8,483 research outputs from this source. They receive a mean Attention Score of 4.4. This one has gotten more attention than average, scoring higher than 61% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 288,412 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 41st percentile – i.e., 41% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 93 others from the same source and published within six weeks on either side of this one. This one is in the 47th percentile – i.e., 47% of its contemporaries scored the same or lower than it.