Title |
Differential effects of garcinol and curcumin on histone and p53 modifications in tumour cells
|
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Published in |
BMC Cancer, January 2013
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DOI | 10.1186/1471-2407-13-37 |
Pubmed ID | |
Authors |
Hilary M Collins, Magdy K Abdelghany, Marie Messmer, Baigong Yue, Sian E Deeves, Karin B Kindle, Kempegowda Mantelingu, Akhmed Aslam, G Sebastiaan Winkler, Tapas K Kundu, David M Heery |
Abstract |
Post-translational modifications (PTMs) of histones and other proteins are perturbed in tumours. For example, reduced levels of acetylated H4K16 and trimethylated H4K20 are associated with high tumour grade and poor survival in breast cancer. Drug-like molecules that can reprogram selected histone PTMs in tumour cells are therefore of interest as potential cancer chemopreventive agents. In this study we assessed the effects of the phytocompounds garcinol and curcumin on histone and p53 modification in cancer cells, focussing on the breast tumour cell line MCF7. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 33% |
Unknown | 2 | 67% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 67% |
Practitioners (doctors, other healthcare professionals) | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 1% |
United States | 1 | 1% |
Unknown | 88 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 19 | 21% |
Researcher | 12 | 13% |
Student > Bachelor | 10 | 11% |
Student > Master | 9 | 10% |
Student > Doctoral Student | 6 | 7% |
Other | 16 | 18% |
Unknown | 18 | 20% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 23 | 26% |
Biochemistry, Genetics and Molecular Biology | 16 | 18% |
Pharmacology, Toxicology and Pharmaceutical Science | 11 | 12% |
Medicine and Dentistry | 7 | 8% |
Chemistry | 4 | 4% |
Other | 9 | 10% |
Unknown | 20 | 22% |